1539318-40-5
Chemical Structure
DFHBI-2T
- CAS No.: 1539318-40-5
- Formula:C12H7F5N2O2
- Molecular Weight:306.19
IUPAC Name: (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-3-methyl-2-(trifluoromethyl)-3,5-dihydro-4H-imidazol-4-one
InChIKey: CGFZNPPTJGGWPN-YWEYNIOJSA-N
SMILES: O=C1N(C)C(C(F)(F)F)=N/C1=C\C2=CC(F)=C(O)C(F)=C2
Biological Activity: DFHBI-2T is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a Kd value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome[1][2].
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DFHBI-2T | 98.0% | DFHBI-2T is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a Kd value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome. | ||||||||||||||||||||
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DFHBI-2T (Standard) | ≥98% | DFHBI-2T (Standard) is the analytical standard of DFHBI-2T (HY-110251A). This product is intended for research and analytical applications. DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells. | ||||||||||||||||||||
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DFHBI-2T (solution) | DFHBI-2T solution is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a Kd value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T solution binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T solution can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome. Solvent and concentration: DMSO: 5 mM |
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