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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Rho-associated
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Rho-associated" in MCE Product Catalog:
429
429 Publications Verification
Cat. No.: HY-10071A
CAS No.: 331752-47-7
Research Areas:
Y-27632 hydrochloride hydrate is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
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6 Cited Publications
Cat. No.: HY-18990
CAS No.: 817194-38-0
Research Areas:
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
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Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
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1 Cited Publications
Synonyms: AR-13324 hydrochloride
Target:
Research Areas:
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
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1 Cited Publications
Synonyms: AR-13324 dimesylate
Target:
Research Areas:
Netarsudil (AR-13324) dimesylate is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil dimesylate reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil dimesylate is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
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Synonyms: RXC007
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .
Cat. No.: HY-162596
CAS No.: 1973494-16-4
Synonyms: BA-1049 free base
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NRL-1049 (BA-1049 (free base)) is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .
Cat. No.: HY-126432
CAS No.: 1973494-17-5
Synonyms: BA-1049
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NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury .
Cat. No.: HY-103045A
CAS No.: 1941168-71-3
Research Areas:
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively) .
Cat. No.: HY-118046
CAS No.: 1123163-20-1
Research Areas:
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
Cat. No.: HY-P701769
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
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Cat. No.: HY-P701770
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
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Cat. No.: HY-P705673
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
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Cat. No.: HY-P86538
Synonyms: ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
Cat. No.: HY-P702931
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-associated, Coiled-Coil-Containing Protein Kinase II; Rho-associated Protein Kinase; Rho-associated Protein Kinase 2; Rho Kinase 2; P
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Cat. No.: HY-P705689
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-associated, Coiled-Coil-Containing Protein Kinase II; Rho-associated Protein Kinase; Rho-associated Protein Kinase 2; Rho Kinase 2; P
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
