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Ruberythric acid

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Ruberythric acid" in MCE Product Catalog:

Ruberythric acid
Ruberythric acid
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Cat. No.: HY-W718178
CAS No.: 152-84-1
Category:  

Polysaccharides Rubiaceae Plants Saccharides Rubia tinctorum L.

Target:  

NF-κB IKK Myosin Claudin Drug Intermediate

Ruberythric acid is a natural product found in madder (Rubia tinctorum). Acid treatment induces hydrolysis of Ruberythric acid, producing pentose-containing sugar residues and alizarin. Ruberythric acid inhibits stimulus-induced phosphorylation of IKK, IκBα and p65 in the NF-κB pathway, regulates tight junction integrity, suppresses stimulus-induced MLCK activation and myosin light chain phosphorylation, reduces tight junction disruption associated with cytoskeletal contraction, alleviates stimulus-induced increase in intestinal permeability, and prevents stimulus-induced redistribution of tight junction proteins. Ruberythric acid forms red salts when dissolved in alkali and can be used as a dye. Ruberythric acid is applicable to research related to inflammatory bowel disease .
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