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Results for "

S1P2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Drug Intermediate (1) Isotope-Labeled Compounds (1) LPL Receptor (25) Reference Standards (3) Small Interfering RNA (siRNA) (2) β-catenin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (9) Neurological Disease (12)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100675

JTE-013 Maximum Cited Publications 10 Publications Verification	LPL Receptor Apoptosis	Cancer
JTE-013 is a potent and specific *S1P₂* (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P₂ with IC₅₀s of 17 nM and 22 nM, respectively .

HY-12355

Siponimod Maximum Cited Publications 10 Publications Verification BAF-312	LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research ^- .

HY-139310

GLPG2938	LPL Receptor	Others
GLPG2938 is a potent and selective *S1P2* antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis .

HY-111253

CYM-5478	LPL Receptor	Neurological Disease
CYM-5478 is a potent and highly selective *S1P₂* agonist with an EC₅₀ of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity .

HY-10968

CYM5442 3 Publications Verification	LPL Receptor	Neurological Disease
CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀ of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R .

HY-108495

CYM50308 1 Publications Verification ML248	LPL Receptor	Cardiovascular Disease
CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P₄-R) agonist with an EC₅₀ of 56 nM. CYM50308 displays 37-fold more selective for S1P₄-R than S1P₅-R. CYM50308 has no activity at S1P₁-R, S1P₂-R and S1P₃-R subtypes at concentrations up to 25 μM .

HY-19511

GSK2018682 1 Publications Verification	LPL Receptor	Inflammation/Immunology
GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC₅₀s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

HY-101939A

RP-001 hydrochloride	LPL Receptor	Neurological Disease
RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC₅₀ of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5 .

HY-12355A

Siponimod hemifumarate Maximum Cited Publications 10 Publications Verification BAF-312 hemifumarate	LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC₅₀s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research .

HY-W009498

2,5-Dibromo-4-methylpyridine	Drug Intermediate	Others
2,5-Dibromo-4-methylpyridine is a synthetic pyridine derivative and serves as an important intermediate .

HY-141845

S1P2 antagonist 1	LPL Receptor	Others
S1P2 antagonist 1 is an orally bioavailable *S1P2* antagonist against fibrotic diseases.

HY-120409

AB1	LPL Receptor Apoptosis	Cancer
AB1 is a highly selective S1P2 receptor antagonist (IC₅₀=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors .

HY-119221

AUY954	LPL Receptor	Neurological Disease Inflammation/Immunology
AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC₅₀ values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis .

HY-12355S

Siponimod-d11 BAF-312-d₁₁	LPL Receptor Isotope-Labeled Compounds	Neurological Disease Inflammation/Immunology
Siponimod-d₁₁ (BAF-312-d₁₁) is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over *S1P₂, S1P₃, and S1P₄, with EC₅₀s* of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

HY-RS12394

S1PR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1PR2 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1PR2 Human Pre-designed siRNA Set A S1PR2 Human Pre-designed siRNA Set A

HY-101939

RP-001	LPL Receptor	Neurological Disease
RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC₅₀ of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5 .

HY-12355R

Siponimod (Standard) BAF-312 (Standard)	Reference Standards LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research ^- .

HY-10968A

CYM5442 hydrochloride	LPL Receptor	Neurological Disease
CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS) .

HY-176057

S118	β-catenin	Inflammation/Immunology
S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P₂ receptor) inhibitor. S118 prevents the binding of the S1P₂ receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P₂ receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis .

HY-100675R

JTE-013 (Standard)	Reference Standards LPL Receptor Apoptosis	Cancer
JTE-013 (Standard) is the analytical standard of JTE-013. This product is intended for research and analytical applications. JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively .

HY-19511A

GSK2018682 hydrochloride	LPL Receptor	Inflammation/Immunology
GSK2018682 hydrochloride is an agonist for S1P1 and S1P5 receptor with pEC₅₀s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 hydrochloride is used in the research of multiple sclerosis.

HY-10968R

CYM5442 (Standard)	LPL Receptor	Neurological Disease
CYM5442 (Standard) is the analytical standard of CYM5442. This product is intended for research and analytical applications. CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .

HY-14402

AMG 369	LPL Receptor	Infection Inflammation/Immunology
AMG 369 is an orally active and potent dual S1P₁/S1P₅ agonist with limited activity at S1P₃ and no activity at S1P₂/S1P₄. AMG 369 reduces blood lymphocyte counts. AMG 369 delays onset and reduces severity of experimental autoimmune encephalomyelitis in rat .

HY-RS12395

S1pr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1pr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr2 Mouse Pre-designed siRNA Set A S1pr2 Mouse Pre-designed siRNA Set A

HY-108495R

CYM50308 (Standard) ML248 (Standard)	Reference Standards LPL Receptor	Cardiovascular Disease
CYM50308 (Standard) is the analytical standard of CYM50308 (HY-108495). This product is intended for research and analytical applications. CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC₅₀ of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM .

HY-164584

S1P5 receptor antagonist 1	LPL Receptor	Neurological Disease
S1P5 receptor antagonist 1 is a selective, blood-brain barrier-permeable S1P5 receptor antagonist with an EC₅₀ of 0.1 nM and a K_i of 4.4 nM. S1P5 receptor antagonist 1 inhibits the migration of natural killer cells towards sphingosine 1-phosphate in vitro, with no effect on T cell migration. S1P5 receptor antagonist 1 can be used in the research of central nervous system diseases .

2,5-Dibromo-4-methylpyridine	Biochemical Assay Reagents
2,5-Dibromo-4-methylpyridine is a synthetic pyridine derivative and serves as an important intermediate .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705541

	S1pr2 Protein, Mouse (Cell-Free, His) Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; Endothelial differentiation G-protein coupled receptor 5; Lysophospholipid receptor B2; Sphingosine 1-phosphate receptor Edg-5 (S1P receptor Edg-5); Edg5; Gpcr13; Lpb2	Mouse	E. coli Cell-free

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HY-12355S

Siponimod-d11
Siponimod-d₁₁ (BAF-312-d₁₁) is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over *S1P₂, S1P₃, and S1P₄, with EC₅₀s* of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

Siponimod-d11

Siponimod-d₁₁ (BAF-312-d₁₁) is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

S1PR2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
S1PR2 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
S1pr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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