1463912-49-3
Chemical Structure
AB1
- CAS No.: 1463912-49-3
- Formula:C19H21Cl2N7O
- Molecular Weight:434.32
IUPAC Name: 2-(1-allyl-4-isopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-N-(2,6-dichloropyridin-4-yl)hydrazine-1-carboxamide
InChIKey: QTRXSBUIHCYTDW-UHFFFAOYSA-N
SMILES: C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21
Biological Activity: AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors[1].
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AB1 | AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors. | |||||||||||||||||||||
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Keywords
