1202073-26-4
1202073-26-4
Chemical Structure
AMG 369
- CAS No.: 1202073-26-4
- Formula:C26H22FN3O2S
- Molecular Weight:459.54
IUPAC Name: 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid
InChIKey: KCMALGDZUKTGJR-UHFFFAOYSA-N
SMILES: O=C(O)C1CN(CC2=CC=C(C(F)=C2)C3=NC=4C=CC(=NC4S3)C5(C=6C=CC=CC6)CC5)C1
Biological Activity: AMG 369 is an orally active and potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4. AMG 369 reduces blood lymphocyte counts. AMG 369 delays onset and reduces severity of experimental autoimmune encephalomyelitis in rat[1].
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AMG 369 | AMG 369 is an orally active and potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4. AMG 369 reduces blood lymphocyte counts. AMG 369 delays onset and reduces severity of experimental autoimmune encephalomyelitis in rat. | |||||||||||||||||||||
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References
Keywords
