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Results for "

SIN 1

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

4

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101200
    Linsidomine hydrochloride

    SIN-1 chloride

    		 Apoptosis Autophagy Reactive Oxygen Species (ROS) Annexin A NF-κB Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn 2+ treated nerve cells .
    Linsidomine hydrochloride
  • HY-N0649
    Narcissin
    5 Publications Verification

    Narcissoside

    		 EBV Neurological Disease Cancer
    Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO - and SIN-1-derived ONOO - with IC50s of 3.5 and 9.6 μM, respectively .
    Narcissin
  • HY-12379
    NS-2028
    1 Publications Verification

    		 Guanylate Cyclase Inflammation/Immunology
    NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity . NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM . NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM . NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) . NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .
    NS-2028
  • HY-149278
    Complement C1s-IN-1

    		Complement System Inflammation/Immunology
    Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM .
    Complement C1s-IN-1
  • HY-101200R
    Linsidomine hydrochloride (Standard)

    SIN-1 chloride (Standard)

    		 Reference Standards Apoptosis Autophagy Reactive Oxygen Species (ROS) Annexin A NF-κB Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Linsidomine (hydrochloride) (Standard) is the analytical standard of Linsidomine (hydrochloride). This product is intended for research and analytical applications. Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn 2+ treated nerve cells .
    Linsidomine hydrochloride (Standard)
  • HY-W371165
    C1s-IN-1 trihydrochloride

    		Complement System Inflammation/Immunology
    C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM .
    C1s-IN-1 trihydrochloride
  • HY-N0649R
    Narcissin (Standard)

    Narcissoside (Standard)

    		 EBV Reference Standards Neurological Disease Cancer
    Narcissin (Standard) is the analytical standard of Narcissin. This product is intended for research and analytical applications. Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO-?and SIN-1-derived ONOO- with IC50s?of 3.5 and 9.6 μM, respectively .
    Narcissin (Standard)
  • HY-139569
    Ebaresdax

    ACP-044

    		 Endogenous Metabolite Neurological Disease
    Ebaresdax (ACP-044) can inhibit peroxynitrite oxidation derived by SIN-1 and peroxynitrite mediated Cytotoxicity with IC50s of 3.7±0.80 and 0.13±0.02 uM, respectively .
    Ebaresdax
  • HY-105668
    Cathepsin S-IN-1

    		Cathepsin Others
    Cathepsin S-IN-1 (example 1) is a Cathepsin S inhibitor .
    Cathepsin S-IN-1
  • HY-139569A
    Ebaresdax hydrochloride

    ACP-044 hydrochloride

    		 Endogenous Metabolite Neurological Disease
    Ebaresdax (ACP-044) hydrochloride can inhibit peroxynitrite oxidation derived by SIN-1 and peroxynitrite mediated Cytotoxicity with IC50s of 3.7±0.80 and 0.13±0.02 uM, respectively .
    Ebaresdax hydrochloride
  • HY-152019
    EGFR/C797S-IN-1

    		EGFR Cancer
    EGFR/C797S-IN-1 is a potent EGFR-C797S inhibitor with an IC50 value of 0.128 µM. EGFR/C797S-IN-1 shows anti-proliferative activity and anti-tumor activity. EGFR/C797S-IN-1 inhibits the expression of p-EGFR in a dose-dependent manner .
    EGFR/C797S-IN-1
  • HY-W371164
    C1s-IN-1

    		Complement System Inflammation/Immunology
    C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM .
    C1s-IN-1
  • HY-183009
    Pf20S-IN-1

    		Proteasome Parasite Infection
    Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC50 of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research .
    Pf20S-IN-1
  • HY-155169
    hLTA4H/hLTA4S-IN-1

    		Endogenous Metabolite Inflammation/Immunology
    hLTA4H/hLTA4S-IN-1 is a possible dual inhibitor that has the activity of inhibiting both human leukotriene hydrolase (hLTA4H) and human leukotriene C4 synthase (hLTC4S). hLTA4H/hLTA4S-IN-1 was identified by computer-assisted methods and is able to effectively interfere with the leukotriene biosynthesis pathway in cells. hLTA4H/hLTA4S-IN-1 can be used to study inflammatory responses .
    hLTA4H/hLTA4S-IN-1

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