C1s-IN-1 trihydrochloride
Based on 1 Customer Validation
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 1376162-36-5
- Formula: C16H22Cl3N5
- Molecular Weight:390.74
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ki: 5.8 μM (C1s protease); 51.2 μM (thrombin)
Chemical Information
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CAS No. 1376162-36-5
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Appearance Solid
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Molecular Weight 390.74
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Formula C16H22Cl3N5
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Color White to light yellow
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SMILES
N=C(C1=CN=C(N2CCN(CC2)C3=CC=CC=C3)C=C1)N.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (255.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (255.92 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5592 mL | 12.7962 mL | 25.5925 mL | 63.9812 mL |
| 5 mM | 0.5118 mL | 2.5592 mL | 5.1185 mL | 12.7962 mL | |
| 10 mM | 0.2559 mL | 1.2796 mL | 2.5592 mL | 6.3981 mL | |
| 15 mM | 0.1706 mL | 0.8531 mL | 1.7062 mL | 4.2654 mL | |
| 20 mM | 0.1280 mL | 0.6398 mL | 1.2796 mL | 3.1991 mL | |
| 25 mM | 0.1024 mL | 0.5118 mL | 1.0237 mL | 2.5592 mL | |
| 30 mM | 0.0853 mL | 0.4265 mL | 0.8531 mL | 2.1327 mL | |
| 40 mM | 0.0640 mL | 0.3199 mL | 0.6398 mL | 1.5995 mL | |
| 50 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2796 mL | |
| 60 mM | 0.0427 mL | 0.2133 mL | 0.4265 mL | 1.0664 mL | |
| 80 mM | 0.0320 mL | 0.1600 mL | 0.3199 mL | 0.7998 mL | |
| 100 mM | 0.0256 mL | 0.1280 mL | 0.2559 mL | 0.6398 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
C1s-IN-1 trihydrochloride Related Classifications
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