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SMARCA2/4-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (1) Epigenetic Reader Domain (5) Ligands for Target Protein for PROTAC (2) Oxidative Phosphorylation (1) PROTACs (2) SWI/SNF Complex (1)
By Research Areas:	Cancer (9)
Click Chemistry:	Azide (3)

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144835

Camibirstat 2 Publications Verification FHD-286	Oxidative Phosphorylation Epigenetic Reader Domain	Cancer
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia .

HY-144897

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of *SMARCA4, SMARCA2* and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .

HY-149458

FHT-2344	Epigenetic Reader Domain	Cancer
FHT-2344, a chemical probe, is a SMARCA4/SMARCA2 ATPase inhibitor with IC₅₀ values of 0.026 μM and 0.013 μM, respectively. FHT-2344 has anticancer activity .

HY-163926

*SMARCA2/4-IN-2*	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-161885

SMARCA2/4-IN-4	SWI/SNF Complex	Cancer
SMARCA2-IN-6 is a *SMARCA2* and SMARCA4 inhibitor, with an IC₅₀ value of <0.005 μM for both *SMARCA2* and *SMARCA4*. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers .

HY-159453

PROTAC SMARCA2/4-degrader-2	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159545

**SMARCA2/4-ligand-2**	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.

HY-162815

PROTAC SMARCA2/4-degrader-26	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) ^{[1] ^.}

HY-159594

Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo	E3 Ligase Ligand-Linker Conjugates	Cancer
Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 Ligase Ligand-Linker Conjugate. Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo can be used to synthesize PROTAC SMARCA2/4-degrader-2 (HY-159453) .

Cat. No.	Product Name		Classification

HY-163926

*SMARCA2/4-IN-2*		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-159453

PROTAC SMARCA2/4-degrader-2		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159545

**SMARCA2/4-ligand-2**		Azide
SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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