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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Stargardt disease
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Stargardt disease" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P76196
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROM1; AC133 Antigen; Prev. PROML1; Prominin-1; Prev. STGD4; Stargardt disease 4 (Autosomal Dominant); Prev. MCDR2; Hematopoietic Stem Cell Antigen; CORD12; Macular Dystrophy, Retinal 2; CD133; Prominin (Mouse)-Like 1; AC133; CD133 Isoform H; RP41; CD133
Species:
Rat
Source:
HEK293
Synonyms: LBS-008; BPN-14967
Target:
Research Areas:
Tinlarebant (LBS-008) is an orally active non-retinoid RBP4 (retinol-binding protein 4) antagonist. Tinlarebant can be used for the research of the Stargardt disease .
Cat. No.: HY-175663
Target:
Research Areas:
EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Cat. No.: HY-175664
Target:
Research Areas:
EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ⁻/⁻ Rdh8 ⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Cat. No.: HY-187175
CAS No.: 2172940-88-2
Target:
Research Areas:
Rp-8-Br-pME-PET-cGMPS is a cGMP (HY-113469) analog. Rp-8-Br-pME-PET-cGMPS is used for research on retinal dystrophy, retinitis pigmentosa, Stargardt disease, and macular degeneration .
Cat. No.: HY-182385
CAS No.: 1628945-93-6
Target:
Research Areas:
BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC50 of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction (IC50 = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease .
Cat. No.: HY-P76197
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROM1; AC133 Antigen; Prev. PROML1; Prominin-1; Prev. STGD4; Stargardt disease 4 (Autosomal Dominant); Prev. MCDR2; Hematopoietic Stem Cell Antigen; CORD12; Macular Dystrophy, Retinal 2; CD133; Prominin (Mouse)-Like 1; AC133; CD133 Isoform H; RP41; CD133
Species:
Rat
Source:
HEK293
Cat. No.: HY-P78732
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: PROM1; AC133 Antigen; Prev. PROML1; Prominin-1; Prev. STGD4; Stargardt disease 4 (Autosomal Dominant); Prev. MCDR2; Hematopoietic Stem Cell Antigen; CORD12; Macular Dystrophy, Retinal 2; CD133; Prominin (Mouse)-Like 1; AC133; CD133 Isoform H; RP41; CD133
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
