TEM-1

By Targets:	Antibiotic (10) Bacterial (14) Beta-lactamase (14) EGFR (1) Isotope-Labeled Compounds (2) Reference Standards (3) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Infection (15)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14879A

Avibactam sodium Maximum Cited Publications 92 Publications Verification NXL-104	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-P99778

Ontuxizumab MORAb-004	EGFR	Cancer
Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer ^[1].

HY-14879

Avibactam free acid Maximum Cited Publications 92 Publications Verification NXL-104 free acid	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879AR

Avibactam sodium (Standard) NXL-104 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium) (Standard) is the analytical standard of Avibactam (sodium). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879B

Avibactam sodium hydrate Maximum Cited Publications 92 Publications Verification NXL-104 hydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-142128

Cymal-6 Cyclohexyl-hexyl-β-D-maltoside	Bacterial	Infection
Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent TEM-1 beta-lactamase inhibitor with an K_i value of 40.05 µM. Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) can be used as glycosidic surfactant ^[1] .

HY-14879S2

Avibactam sodium salt-13C5 NXL-104-¹³C₅	Isotope-Labeled Compounds Antibiotic Beta-lactamase Bacterial	Infection
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1] .

HY-U00380

Tigemonam	Antibiotic Beta-lactamase Bacterial	Infection
Tigemonam is an orally active monobactam antibiotic with a K_i of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection ^[1] .

HY-14879BR

Avibactam sodium hydrate (Standard) NXL-104 hydrate (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium hydrate) (Standard) is the analytical standard of Avibactam (sodium hydrate). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

HY-14879E

rel-Avibactam sodium NXL-104 sodium	Beta-lactamase Bacterial	Infection
Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC₅₀ value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes ^[1] .

HY-14879C

Avibactam sodium dihydrate NXL-104 dihydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

HY-14879R

Avibactam free acid (Standard) NXL-104 free acid (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid). This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

HY-128049

ML121	Beta-lactamase	Infection
ML121 is a selective and potent VIM-2 inhibitor with an IC₅₀ of 54 nM and a K_i of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli ^[1].

HY-14879D

ent-Avibactam sodium AVE1330A	Beta-lactamase Bacterial	Infection
Ent-Avibactam sodium (AVE1330A) is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), ent-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC₅₀ value of ent-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes ^[1].

HY-RS02215

CD248 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD248 Human Pre-designed siRNA Set A contains three designed siRNAs for CD248 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD248 Human Pre-designed siRNA Set A CD248 Human Pre-designed siRNA Set A

HY-RS18990

Cd248 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd248 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd248 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd248 Mouse Pre-designed siRNA Set A Cd248 Mouse Pre-designed siRNA Set A

HY-105560

Cefcanel	Bacterial Beta-lactamase	Infection
Cefcanel is an orally active cephalosporin and antibacterial agent. Cefcanel inhibits growth of methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, Haemophilus influenzae, Moraxella catarrhalis. Cefcanel acts as a substrate hydrolyzed by *TEM-1, TEM-3, and Moraxella* Bro-1 beta-lactamases ^[1].

HY-14879S7

Avibactam-13C5,15N sodium NXL-104-13C5,15N sodium	Isotope-Labeled Compounds Antibiotic Beta-lactamase Bacterial	Infection
Avibactam- ¹³C₅,15N sodium (NXL-104- ¹³C₅, ¹⁵N sodium) is the ¹³C- and ¹⁵N-labeled Avibactam (HY-14879). Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99778

Ontuxizumab MORAb-004	EGFR	Cancer
Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer ^[1].

Species:	Human (1) Mouse (1) E.coli (1) Canine (1)
Tag:	His (4)
Source:	HEK293 (3) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700831

	Endosialin/CD248 Protein, Canine (HEK293, His) Endosialin; CD248; CD164L1; TEM1; CD164 sialomucin-like 1; CD164L1; CD248 molecule	Canine	HEK293
	Endosialin/CD248 Protein potentially plays a role in angiogenesis or vascular function, suggesting involvement in blood vessel formation or vascular regulation. The exact mechanisms and contexts of Endosialin/CD248 in these processes are areas of interest, emphasizing its potential significance in vascular development and function. Endosialin/CD248 Protein, Canine (HEK293, His) is the recombinant canine-derived Endosialin/CD248 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78043

	Endosialin/CD248 Protein, Mouse (HEK293, His) Endosialin; CD248; CD164L1; TEM1; CD164 sialomucin-like 1; CD164L1; CD248 molecule; MGC119479	Mouse	HEK293
	Endosialin/CD248 Protein potentially plays a role in angiogenesis or vascular function, suggesting involvement in blood vessel formation or vascular regulation. The exact mechanisms and contexts of Endosialin/CD248 in these processes are areas of interest, emphasizing its potential significance in vascular development and function. Endosialin/CD248 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endosialin/CD248 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71804

	*Beta-lactamase TEM/Bla Protein, E.coli (P.pastoris, His)* bla; blaT-3; blaT-4; blaT-5; TEM-1; TEM-16/CAZ-7; TEM-2; TEM-24/CAZ-6; TEM-3; TEM-4; TEM-5; TEM-6; TEM-8/CAZ-2	E.coli	P. pastoris
	The β-lactamase TEM/Bla proteome is dominant in Enterobacteriaceae and hydrolyzes β-lactam bonds in β-lactam antibiotics, thereby conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 hydrolyze cefotaxime and ceftazidime, TEM-5 targets ceftazidime, and TEM-6 includes aztreonam. Beta-lactamase TEM/Bla Protein, E.coli (P.pastoris, His) is the recombinant E. coli-derived Beta-lactamase TEM/Bla protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P78042

	Endosialin/CD248 Protein, Human (HEK293, His) Endosialin; CD248; CD164L1; TEM1; CD164 sialomucin-like 1; CD164L1; CD248 molecule; MGC119479	Human	HEK293
	Endosialin/CD248 Protein may contribute to tumor angiogenesis. Endosialin/CD248 Protein, Human (HEK293, His) is the recombinant human-derived Endosialin/CD248 protein, expressed by HEK293 , with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase *TEM-1* and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1] .

HY-14879S7

Avibactam-13C5,15N sodium
Avibactam- ¹³C₅,15N sodium (NXL-104- ¹³C₅, ¹⁵N sodium) is the ¹³C- and ¹⁵N-labeled Avibactam (HY-14879). Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively ^[1].

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	WB (1) FC (2) ELISA (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84811

	CD248 Antibody (YA4508) TEM1; CD164L1	FC, ELISA	Human
	CD248 Antibody (YA4508) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD248.

HY-P84811A

	CD248 Antibody (YA4508)(PBS only) TEM1; CD164L1	WB, FC, ELISA	Human
	CD248 Antibody (YA4508) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD248.

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Cat. No.	Product Name		Classification

HY-RS02215

CD248 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD248 Human Pre-designed siRNA Set A contains three designed siRNAs for CD248 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18990

Cd248 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cd248 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd248 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

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