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Isoforms Recommended:	TRPV4

Results for "

TRPV4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Calcium Channel (2) CHIKV (1) Endogenous Metabolite (2) Environmental Pollutants (1) FAAH (1) NO Synthase (1) Parasite (2) Potassium Channel (1) Reference Standards (4) Small Interfering RNA (siRNA) (4) TRP Channel (43)
By Research Areas:	Cancer (7) Cardiovascular Disease (12) Infection (3) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) siRNA drugs (1) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100208

HC-067047 Maximum Cited Publications 41 Publications Verification	TRP Channel	Cancer
HC-067047 is a potent and selective *TRPV4* antagonist and reversibly inhibits currents through the human, rat, and mouse *TRPV4* orthologs with IC₅₀ values of 48 nM, 133 nM, and 17 nM, respectively .

HY-19608

GSK1016790A 35+ Cited Publications	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-100720

GSK2193874 15+ Cited Publications	TRP Channel	Cardiovascular Disease
GSK2193874 is an orally active, potent, and selective *TRPV4* antagonist with IC₅₀s of 2 nM and 40 nM for *rTRPV4* and *hTRPV4* .

HY-120691A

GSK205 10+ Cited Publications	TRP Channel	Metabolic Disease Inflammation/Immunology
GSK205 is a potent, selective *TRPV4* antagonist with an IC₅₀ of 4.19 μM for inhibiting *TRPV4*-mediated Ca ²⁺ influx .

HY-19975

RN-1734 5+ Cited Publications	TRP Channel	Neurological Disease Cancer
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC₅₀s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .

HY-116291

4α-Phorbol 12,13-didecanoate 4αPDD	TRP Channel CHIKV	Infection Inflammation/Immunology
4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca ²⁺ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) ^[4].

HY-19765

GSK2798745 5+ Cited Publications	TRP Channel	Cardiovascular Disease
GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC₅₀s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research .

HY-101507

Zerencotrep 10+ Cited Publications Pico145; HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-18662

RQ-00203078 5+ Cited Publications	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-B1177

Crotamiton	Environmental Pollutants TRP Channel Parasite	Infection
Crotamiton is a *TRPV4* inhibitor. Crotamiton inhibits *TRPV4* currents. Crotamiton inhibits *TRPV4* selective agonist-induced pruritus-related behaviors in mice. Crotamiton inhibits Histamine- and Chloroquine-induced calcium influx via the *H1R/TRPV1,* MRGPRA3/TRPA1 pathways, and also suppresses calcium influx in primary mouse dorsal root ganglion neurons. Crotamiton is applicable to research related to pruritus, scabies, and non-scabietic pruritus .

HY-157131

TRPV2-selective blocker 1 2 Publications Verification	TRP Channel	Neurological Disease
TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC₅₀of 6.3 μM against rat *TRPV2, and shows no activity against TRPV1, TRPV3* or *TRPV4* channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral *TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2* during immune processes .

HY-19976

RN-1747 5 Publications Verification	TRP Channel	Cardiovascular Disease
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC₅₀ values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC₅₀ of 4 μM .

HY-114400

TRPV4 agonist-1 free base	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC₅₀ of 60 nM in the hTRPV4 Ca ²⁺ assay .

HY-132596A

Tivanisiran sodium SYL1001 sodium	Small Interfering RNA (siRNA) TRP Channel	Neurological Disease
Tivanisiran sodium (SYL1001 sodium) is a small interfering RNA (siRNA) targeting *TRPV1* . Tivanisiran sodium induces the degradation of *TRPV1* mRNA, thereby inhibiting protein synthesis. Tivanisiran sodium alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran sodium is applicable to research related to dry eye disease .

HY-160603

PF-05214030	TRP Channel	Others
PF-05214030 is a *TRPV4* antagonist (IC₅₀: 4 and 27nM for hTRPV4 and rTRPV4 respectively). PF-05214030 reverses the reduction in bladder capacity caused by intravesical infusion of a TRPV4 agonist .

HY-160900

RN-1665 1 Publications Verification	TRP Channel	Others
RN-1665 is an orally active *TRPV4* antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively .

HY-149823

TRPV4 antagonist 4	TRP Channel	Neurological Disease
TRPV4 antagonist 4 is a potent *TRPV4* antagonist with an IC₅₀ value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury .

HY-120962

N-Arachidonoyl Taurine	TRP Channel	Metabolic Disease
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid *TRPV1* and *TRPV4, with EC₅₀*s value of 28 μM and 21 μM, respectively .

HY-114400A

TRPV4 agonist-1	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

HY-120963

N-Oleoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.

HY-176464

GSK2220691	TRP Channel	Inflammation/Immunology
SK2220691 is a potent *TRPV4* inhibitor. SK2220691 inhibits pulmonary edema induced by GSK1016790. SK2220691 inhibits HCl-induced increases in key factors such as VEGF, keratinocyte-derived chemokine (KC; CXCL1), and granulocyte colony-stimulating factor (GCSF) .

HY-142620

TRPV4 antagonist 3	TRP Channel	Cardiovascular Disease
TRPV4 antagonist 3 is a *TRPV4* antagonist (pIC₅₀ = 8.4).

HY-RS15124

TRPV4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPV4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPV4 Human Pre-designed siRNA Set A TRPV4 Human Pre-designed siRNA Set A

HY-162765

TRPV4-IN-5	TRP Channel	Inflammation/Immunology
TRPV4-IN-5 (Compound 1f) is a potent *TRPV4* inhibitor (IC₅₀ = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice .

HY-112202

GSK3395879	TRP Channel	Cardiovascular Disease
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC₅₀ of 1 nM for hTRPV4 .

HY-110270

RN-9893	TRP Channel	Inflammation/Immunology
RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively .

HY-178509

TRPV4-KCa2.3 modulator 1	TRP Channel	Cardiovascular Disease
TRPV4-KCa2.3 modulator 1 (Compound IB-2) is a TRPV4-KCa2.3 protein complex enhancer with antihypertensive activity. TRPV4-KCa2.3 modulator 1 enhances endothelial cell hyperpolarization and vasodilatio. TRPV4-KCa2.3 modulator 1 is promising for research of hypertension and cardiovascular disorders .

HY-185006

TRPV4 antagonist 5	TRP Channel	Others
TRPV4 antagonist 5 (Example 21) is a *TRPV4* antagonist .

HY-W721480

HC-067047 hydrochloride	TRP Channel	Neurological Disease
HC-067047 hydrochloride is a potent and selective *TRPV4* antagonist and reversibly inhibits currents through the human, rat, and mouse *TRPV4* orthologs with IC₅₀ values of 48 nM, 133 nM, and 17 nM, respectively .

HY-RS16623

Trpv4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpv4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpv4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpv4 Mouse Pre-designed siRNA Set A Trpv4 Mouse Pre-designed siRNA Set A

HY-RS23058

Trpv4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpv4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpv4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpv4 Rat Pre-designed siRNA Set A Trpv4 Rat Pre-designed siRNA Set A

HY-126720

N-Lignoceroyl Taurine	Endogenous Metabolite	Metabolic Disease
N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH ^-/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.

HY-117372

DFL23448	TRP Channel	Metabolic Disease
DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC₅₀ values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC₅₀ >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats .

HY-124001

N-Docosanoyl taurine	TRP Channel	Neurological Disease
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions .

HY-157712

08:0 PI(4,5)P2 ammonium	Biochemical Assay Reagents	Others
08:0 PI(4,5)P2 ammonium is suitable for identifying its binding site at the transient receptor potential vanilloid 4 (TRPV 4 N) terminus .

HY-178236

TRPM5 agonist-1	TRP Channel	Metabolic Disease
TRPM5 agonist-1 is an orally active TRPM5 agonist with a pEC₅₀ of 8.1. TRPM5 agonist-1 shows excellent selectivity (> 100-fold) versus related cation channels (TRPM8, TRPV1, TRPV4, TRPA1, TRPM4). TRPM5 agonist-1 exhibits locally acting stimulatory effect on gastrointestinal transit in mice. TRPM5 agonist-1 can be used for research on promoting gastric motility .

HY-110270A

RN-9893 hydrochloride	TRP Channel	Inflammation/Immunology
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC₅₀ values of 0.42 and 0.66 μM, for humans and rats, respectively .

HY-122692

TRPV4/TRPA1-IN-1	TRP Channel	Neurological Disease Inflammation/Immunology
TRPV4/TRPA1-IN-1 is a *TRPV4/TRPA1* inhibitor that suppresses TRPV4/TRPA1-mediated calcium influx. TRPV4/TRPA1-IN-1 alleviates pain behaviors in a mouse trigeminal stimulation pain model and inhibits inflammation and pain-related behaviors in a mouse acute pancreatitis model. TRPV4/TRPA1-IN-1 can be used in research on acute pancreatitis .

HY-120514

JNc-440	TRP Channel Potassium Channel	Cardiovascular Disease
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of *TRPV4* and Ca ²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice .

HY-B1177R

Crotamiton (Standard)	Reference Standards Parasite TRP Channel	Infection
Crotamiton (Standard) is the analytical standard of Crotamiton. This product is intended for research and analytical applications. Crotamiton is a *TRPV4* inhibitor. Crotamiton inhibits *TRPV4* currents. Crotamiton inhibits *TRPV4* selective agonist-induced pruritus-related behaviors in mice. Crotamiton inhibits Histamine- and Chloroquine-induced calcium influx via the *H1R/TRPV1,* MRGPRA3/TRPA1 pathways, and also suppresses calcium influx in primary mouse dorsal root ganglion neurons. Crotamiton is applicable to research related to pruritus, scabies, and non-scabietic pruritus .

HY-N2940

Bisandrographolide A BAA	TRP Channel	Cardiovascular Disease Inflammation/Immunology
Bisandrographolide A (BAA) activates TRPV4 channel with an EC₅₀ of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

HY-182455

GSK3527497	TRP Channel	Cardiovascular Disease
GSK3527497 is an orally active *TRPV4* inhibitor. GSK3527497 is applicable for the research of heart failure .

HY-183906

GSK3491943	TRP Channel	Cardiovascular Disease
GSK3491943 is an antagonist of the transient receptor potential vanilloid subtype 4 (TRPV4) ion channel. GSK3491943 is applicable to research related to pulmonary edema induced by heart failure .

HY-100208R

HC-067047 (Standard)	TRP Channel Reference Standards	Cancer
HC-067047 (Standard) is the analytical standard of HC-067047 (HY-100208). This product is intended for research and analytical applications. HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively .

HY-181463

20-Hydroxy-N-arachidonoyl taurine	TRP Channel FAAH	Others
20-Hydroxy-N-arachidonoyl taurine (Compound C20:4 NAT) acts as an activator of *TRPV1* and *TRPV4, with EC₅₀* values of 28 µM and 21 µM, respectively. 20-Hydroxy-N-arachidonoyl taurine serves as a substrate for fatty acid amide hydrolase (FAAH) .

HY-100720R

GSK2193874 (Standard)	TRP Channel Reference Standards	Cardiovascular Disease
GSK2193874 (Standard) is the analytical standard of GSK2193874 (HY-100720). This product is intended for research and analytical applications. GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50s of 2 nM and 40 nM for rTRPV4 and hTRPV4 .

HY-186172

KS0365	TRP Channel Calcium Channel	Metabolic Disease
KS0365 is a selective *TRPV3* agonist with an EC₅₀ of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca ²⁺]_i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing .

HY-P5315

eNOS pT495 decoy peptide	NO Synthase	Others
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research .

HY-101507R

Zerencotrep (Standard) Pico145 (Standard); HC-608 (Standard)	TRP Channel Reference Standards	Cancer
Zerencotrep (Standard) is the analytical standard of Zerencotrep (HY-101507). This product is intended for research and analytical applications. Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

Cat. No.	Product Name	Target	Research Area