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Transverse aortic constriction (TAC) model

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Tamarixetin
Tamarixetin
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Cat. No.: HY-N1181
CAS No.: 603-61-2
Synonyms: 4'-O-Methyl Quercetin
Category:  

Flavonols Tamarix chinensis Lour. Plants Endogenous metabolite Tamaricaceae Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)

Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
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