Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Tregs differentiation
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Tregs differentiation" in MCE Product Catalog:
3
Target:
Research Areas:
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .
2
2 Cited Publications
Target:
Research Areas:
AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. Has potential to treat asthma . AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer .
1
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-N0723
CAS No.: 64809-67-2
1
1 Cited Publications
Cat. No.: HY-P2294A
Target:
Research Areas:
1
1 Cited Publications
Synonyms: VTP-43742 hydrochloride
Target:
Research Areas:
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research .
Synonyms: Sulfolithocholic acid disodium; LCAS disodium
Cat. No.: HY-B0172AS
CAS No.: 2410277-69-7
Synonyms: 3β-Hydroxy-5α-cholanic acid-d2
Cat. No.: HY-P990796
Target:
Research Areas:
Cat. No.: HY-103637
CAS No.: 1802706-04-2
Synonyms: VTP-43742
Target:
Research Areas:
Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research .
Cat. No.: HY-P2294
Target:
Research Areas:
Cat. No.: HY-P990800
Target:
Research Areas:
Cat. No.: HY-B0172AR
CAS No.: 2276-93-9
Synonyms: 3β-Hydroxy-5α-cholanic acid (Standard)
Target:
Research Areas:
Isoallolithocholic acid (Standard) is the analytical standard of Isoallolithocholic acid. This product is intended for research and analytical applications. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1].
Cat. No.: HY-P4790
CAS No.: 305815-28-5
Research Areas:
Cat. No.: HY-N16465
CAS No.: 97233-06-2
Cat. No.: HY-B0172AS1
CAS No.: 2410277-60-8
Synonyms: 3β-Hydroxy-5α-cholanic acid-d4
Cat. No.: HY-N0723R
CAS No.: 64809-67-2
Cat. No.: HY-P990177
Target:
Research Areas:
Cat. No.: HY-N17465
CAS No.: 526222-27-5
Target:
Cat. No.: HY-183074
Target:
Research Areas:
RO8323 is an orally active, selective CDK8/CDK19 inhibitor, with an IC50 of 2 nM against CDK8 and 3 nM against CDK19. RO8323 promotes regulatory T cell differentiation, inhibits effector T cell generation, reverses the Teff/Treg ratio, upregulates IL-10 production in myeloid cells, and suppresses the production of TNF-α, IL-6 and IL-12. RO8323 enhances immune reconstitution and prolongs cardiac allograft survival in a dose-dependent manner. RO8323 can be used in the research of chronic graft-versus-host disease, cardiac allograft rejection, acute graft-versus-host disease and experimental autoimmune encephalomyelitis .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
