pm26TGF-β1 peptide TFA

Name: pm26TGF-β1 peptide TFA
Brand: MedChemExpress
SKU: HY-P2294A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P2294A Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

pm26TGF-β1 peptide TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2550	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of pm26TGF-β1 peptide TFA:

pm26TGF-β1 peptide Get quote

1 Publications Citing Use of MCE pm26TGF-β1 peptide TFA

•Exp Ther Med. 2021 Feb;21(2):120. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TGF-β1 receptor^[1]^[2]

In Vitro

The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

pm26TGF-β1 peptide (100-1000 µg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1506.58

Formula

C₅₆H₉₄F₃N₁₉O₂₂S₂

Appearance

Solid

Color

White to off-white

Sequence

Ala-Cys-Glu-Ser-Pro-Leu-Lys-Arg-Gln-Cys-Gly-Gly-Gly-Ser

Sequence Shortening

ACESPLKRQCGGGS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (66.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6638 mL	3.3188 mL	6.6375 mL
5 mM	0.1328 mL	0.6638 mL	1.3275 mL
10 mM	0.0664 mL	0.3319 mL	0.6638 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (243 KB) LCMS (261 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Emília R Vaz, et al. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116. [Content Brief]

[2]. Rodrigues, Tamiris Sabrina. Evaluation of the action of the synthetic peptide pm26TGF-β1, human TGF-β1 mimetic, on TNF-α induced apoptosis in Drosophila melanogaster. Universidade Federal de Uberlândia, 2017.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6638 mL	3.3188 mL	6.6376 mL	16.5939 mL
	5 mM	0.1328 mL	0.6638 mL	1.3275 mL	3.3188 mL
	10 mM	0.0664 mL	0.3319 mL	0.6638 mL	1.6594 mL
	15 mM	0.0443 mL	0.2213 mL	0.4425 mL	1.1063 mL
	20 mM	0.0332 mL	0.1659 mL	0.3319 mL	0.8297 mL
	25 mM	0.0266 mL	0.1328 mL	0.2655 mL	0.6638 mL
	30 mM	0.0221 mL	0.1106 mL	0.2213 mL	0.5531 mL
	40 mM	0.0166 mL	0.0830 mL	0.1659 mL	0.4148 mL
	50 mM	0.0133 mL	0.0664 mL	0.1328 mL	0.3319 mL
	60 mM	0.0111 mL	0.0553 mL	0.1106 mL	0.2766 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.