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By Targets:	Adenosine Receptor (1) Adrenergic Receptor (1) Akt (2) Antibiotic (1) Apoptosis (19) Autophagy (2) Bacterial (3) Bcl-2 Family (3) c-Met/HGFR (1) Carbonic Anhydrase (90) Caspase (4) CDK (5) COX (5) DNA/RNA Synthesis (1) Drug Derivative (2) Endogenous Metabolite (3) ERK (2) Factor Xa (7) Ferroptosis (1) Fungal (1) HDAC (3) HIF/HIF Prolyl-Hydroxylase (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) Kallikrein (2) Ligands for Target Protein for PROTAC (1) LOX-1 (1) LRRK2 (2) MDM-2/p53 (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) MMP (1) NAMPT (1) NOD-like Receptor (NLR) (1) Notch (1) P-glycoprotein (1) Parasite (3) PARP (1) PDGFR (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Potassium Channel (2) PROTACs (1) Proteasome (1) Reactive Oxygen Species (ROS) (4) Reference Standards (1) Ser/Thr Protease (2) STAT (1) Thrombin (2) VEGFR (6) Wnt (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (86) Cardiovascular Disease (7) Infection (6) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (11)
Click Chemistry:	Azide (2)

114

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13513

U-104 Maximum Cited Publications 8 Publications Verification SLC-0111	Carbonic Anhydrase	Cancer
U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model .

HY-P4245

D-Pro-Phe-Arg-Chloromethylketone	Factor Xa Kallikrein	Cardiovascular Disease Neurological Disease
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation .

HY-P99631

Garadacimab 1 Publications Verification CSL312	Factor Xa	Cardiovascular Disease
Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting *activated factor XII* (FXIIa)**. Garadacimab has the potential for hereditary angioedema research .

HY-12465

Z-Ile-Leu-aldehyde 2 Publications Verification Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII	Notch γ-secretase Apoptosis	Cancer
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch .

HY-32004

Coumalic acid	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)	Infection
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-155150

*JH-XII-03-02*	LRRK2 PROTACs	Cancer
JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research .

HY-110243

CAIX Inhibitor S4 1 Publications Verification	Carbonic Anhydrase	Cancer
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a K_i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (K_i=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-76779

4-(Chloromethyl)-7-hydroxycoumarin	Drug Derivative	Cancer
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .

HY-116171

(Rac)-Calpain Inhibitor XII	Proteasome	Cardiovascular Disease Neurological Disease
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, K_i=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, K_i=120 nM) and cathepsin B (K_i=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury .

HY-126809A

Bz-Pro-Phe-Arg-pNA hydrochloride Bz-PFR-pNA hydrochloride	Factor Xa	Others
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) hydrochloride is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA hydrochloride can be used in Factor XII assay .

HY-146206

HCAIX-IN-1	Carbonic Anhydrase	Cancer
HCAIX-IN-1 (compound 21e) is a potent and selective HCAIX inhibitor with K_Is of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively .

HY-173053

HDAC-IN-87	HDAC Fungal	Infection
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD₅₀ of greater than 500 mg/kg in male and female rats .

HY-146819

CAIX/CAXII-IN-1	Carbonic Anhydrase	Cancer
Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC₅₀ values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.

HY-147984

hCAXII-IN-3	Carbonic Anhydrase	Cancer
hCAXII-IN-3 (Compound 6o) is a selective *human carbonic anhydrase XII* (hCAXII) inhibitor with a K_i** of 10.0 nM .

HY-177016

LRRK2-IN-19	Ligands for Target Protein for PROTAC LRRK2	Neurological Disease
LRRK2-IN-19 is a PROTAC target protein ligand that can be used to synthesize PROTAC JH-XII-03-02 (HY-155150). JH-XII-03-02 is a highly potent and selective LRRK2 PROTAC degrader, which can be used in Parkinson's disease research .

HY-156169

*hCAIX/XII-IN-7*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and *XII* inhibitor with K_is of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research .

HY-162063

*hCAIX/XII-IN-9*	Carbonic Anhydrase	Inflammation/Immunology Cancer
hCAIX/XII-IN-9 (compound 8) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 1658 nM, 184.8 nM, 8.9 nM, 64.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively .

HY-151472

*hCAIX/XII-IN-6*	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-146979

*hA2A/hCA XII* modulator 1**	Adenosine Receptor Carbonic Anhydrase	Cancer
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K_is of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .

HY-77036R

Furagin (Standard) Furazidine (Standard); Furazidin (Standard)	Reference Standards Antibiotic Bacterial Carbonic Anhydrase	Infection Cancer
Furagin (Standard) is the analytical standard of Furagin. This product is intended for research and analytical applications. Furagin (Furazidine) is an analogue of Nitrofurantoin (HY-A0090) and has antibacterial activity. Furagin also inhibits human carbonic anhydrases (K_is: 260 and 57 nM for hCA IX and XII, respectively) .

HY-179271

CA/HDAC-IN-1	Carbonic Anhydrase HDAC	Cancer
CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with K_i values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC₅₀ values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-P5871

Jingzhaotoxin-XII JzTx-XII	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) is a specific Kv4.1 channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII interacts with the channels by modifying the gating behavior .

HY-P5871A

*Jingzhaotoxin-XII* TFA** JzTx-XII TFA	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific Kv4.1 channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII TFA interacts with the channels by modifying the gating behavior .

HY-149402

*hCA XII-IN-6*	Carbonic Anhydrase	Cancer
hCA XII-IN-6 (compound 4d) is a potent hCA XII inhibitor with a K_i value of 84.2 nM. hCA XII-IN-6 has anti-proliferative activity. hCA XII-IN-6 can be used in research of cancer .

HY-146988

*hCAIX/XII-IN-1*	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-1 is a potent *CAIX/XII* inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells .

HY-163414

*hCAIX/XII-IN-11*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII with a K_i value of 0.7 μM for both the isoforms. hCAIX/XII-IN-11 can be used for anticancer research .

HY-173394

*hCAIX/XII-IN-15*	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, with K_is of 0.42 and 4.37 μM respectively. hCAIX/XII-IN-15 has pro-apoptotic effect in multiple myeloma cells .

HY-150695

*hCAIX/XII-IN-5*	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (K_i=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis .

HY-161295

*hCAIX/XII-IN-10*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-10 (compound DK-8) is a carbonic anhydrase inhibitor. hCAIX/XII-IN-10 has potent inhibitory activity against tumor-associated membrane-bound isoforms hCA IX and *XII*, with K_i values of 32.5 nM and 29.2 nM .

HY-156181

*hCAIX/XII-IN-8*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and *XII* inhibitor, with K_i values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II .

HY-172178

*hCAIX/XII-IN-14*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-14 (Compound 1i) is an *hCAIX/XII* inhibitor, with K_i values of hCAII, hCAIX, and hCAXII for 9.4 nM, 5.6 nM, and 6.3 nM, respectively .

HY-162000

*hCAIX/XII-IN-13*	Apoptosis	Cancer
hCAIX/XII-IN-13 is an inhibitor of human carbonic anhydrases (hCA). hCAIX/XII-IN-13 shows good inhibitory activity against the tumor-related CA subtypes IX and XII, with K_i values of 0.08 µM and 0.06 µM, respectively. Under hypoxic conditions, hCAIX/XII-IN-13 can restore the cytotoxicity of Doxorubicin (HY-15142A) on MCF-7 cells, increasing G₂/M phase cell cycle arrest and apoptosis .

HY-146259

*hCAIX/XII-IN-4*	Carbonic Anhydrase	Others
hCAIX/XII-IN-4 (compound 6c) is a potent *CAIX/XII* inhibitor with the K_i values of 4.5 nM, 23.6 nM, >10000 nM and >10000 nM for CAXII, CAIX, CAI and CAⅡ, respectively .

HY-W306065

*hCAI/II/XII-IN-1*	Carbonic Anhydrase	Cancer
hCAI/II/XII-IN-1 (compound 7) is a human carbonic anhydrase *hCAI/II/XII* inhibitor, with K_i values of 78.5, 9.1, 605, 7.7 and 3.7 nM .

HY-147799

*hCA XII/II/IX-IN-1*	Carbonic Anhydrase	Cancer
hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC₅₀ values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity .

HY-146252

hCAXII-IN-4	Carbonic Anhydrase	Cancer
hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an K_i value of 6.4 nM for human CA XII .

HY-N15231

Dipsacus saponin XII	Endogenous Metabolite Phosphatase	Cancer
Dipsacus saponin XII (compound 6) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM) .

HY-146257

*hCAIX/XII-IN-2*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-2 (compound 6a) is a potent and selective hCAIX and hCAXIIinhibitor with K_i values of >10000, >10000, 30.0, 3.6 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .

HY-146258

*hCAIX/XII-IN-3*	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with K_i values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .

HY-168856

*hCAII/XII-IN-1*	Carbonic Anhydrase	Cancer
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with K_is of 8.4 and 9.4 nM, respectively. hCAXII-IN-11 plays an important role in cancer research .

HY-147829

hCAXII-IN-2	Carbonic Anhydrase	Cancer
hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with K_i values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II .

HY-172899

Carbonic anhydrase inhibitor 33	Carbonic Anhydrase Apoptosis CDK	Cancer
Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with K_i values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC .

HY-146207

HCAIX-IN-2	Carbonic Anhydrase	Cancer
HCAIX-IN-2 (compound 9d) is a selective carbonic anhydrase inhibitor with the K_i values of 24.6 nM and 45.3 nM for hCA IX and hCA XII, respectively .

HY-159982

SH7s	Carbonic Anhydrase	Cancer
SH7s is a potent carbonic anhydrases inhibitor, with K_is of 15.9 and 55.2 nM for hCA IX and hCA XII, respectively. SH7s is also a hypoxia-mediated chemo-sensitizing agent in colorectal cancer cells .

HY-144641

Carbonic anhydrase inhibitor 7	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-144640

Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-126809

Bz-Pro-Phe-Arg-pNA Bz-PFR-pNA	Kallikrein Ser/Thr Protease Parasite Factor Xa	Others
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA can be used in Factor XII assay .

Cat. No.	Product Name	Type

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Biochemical Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Biochemical Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

Cat. No.	Product Name	Target	Research Area

HY-P4245

D-Pro-Phe-Arg-Chloromethylketone	Factor Xa Kallikrein	Cardiovascular Disease Neurological Disease
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation .

HY-126809A

Bz-Pro-Phe-Arg-pNA hydrochloride Bz-PFR-pNA hydrochloride	Factor Xa	Others
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) hydrochloride is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA hydrochloride can be used in Factor XII assay .

HY-P5871

Jingzhaotoxin-XII JzTx-XII	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) is a specific Kv4.1 channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII interacts with the channels by modifying the gating behavior .

HY-P5871A

*Jingzhaotoxin-XII* TFA** JzTx-XII TFA	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific Kv4.1 channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII TFA interacts with the channels by modifying the gating behavior .

HY-126809

Bz-Pro-Phe-Arg-pNA Bz-PFR-pNA	Kallikrein Ser/Thr Protease Parasite Factor Xa	Others
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA can be used in Factor XII assay .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99631

Garadacimab 1 Publications Verification CSL312	Factor Xa	Cardiovascular Disease
Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting *activated factor XII* (FXIIa)**. Garadacimab has the potential for hereditary angioedema research .

HY-P991993

AB054	Factor Xa	Cardiovascular Disease
AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis .

Species:	Human (2) Mouse (2) Cynomolgus (1) Pig (2)
Tag:	His (7) Avi (2)
Source:	HEK293 (4) P. pastoris (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7716

	CA12/Carbonic Anhydrase 12 Protein, Mouse (HEK293, His) rMuCarbonic Anhydrase 12, His; Carbonic anhydrase 12; Carbonate dehydratase XII; CA-XII; CA12; Carbonate dehydratase XII;	Mouse	HEK293
	CA12/Carbonic Anhydrase 12 Protein, Mouse (HEK293, His), a recombinant Mouse Carbonic Anhydrase 12 produced in HEK293 cells, has a His tag at the N-terminus. Hypoxic tumors overexpress two carbonic anhydrases (CA), CA IX and XII, involved in complex processes connected to tumorigenesis (pH regulation, metabolism, invasion, and dissemination of the tumor).

HY-P705171

	CA12/Carbonic anhydrase 12 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) Carbonic anhydrase; CA12; Carbonate dehydratase XII; CA-XII	Cynomolgus	HEK293

HY-P72866

	CA12/Carbonic Anhydrase 12 Protein, Human (HEK293, His) Carbonic anhydrase 12; Carbonate dehydratase XII; CA-XII; CA12	Human	HEK293
	CA12 (or carbonic anhydrase 12) plays a crucial role in the reversible hydration of carbon dioxide, catalyzing its conversion into bicarbonate ions and protons. This enzymatic activity is essential for key physiological processes, including regulating pH and maintaining acid-base balance. CA12/Carbonic Anhydrase 12 Protein, Human (HEK293, His) is the recombinant human-derived CA12/Carbonic Anhydrase 12 protein, expressed by HEK293 , with C-His labeled tag.

HY-P705172

	CA12/Carbonic Anhydrase 12 Protein, Mouse (Biotinylated, HEK293, His-Avi) CA12; Carbonate dehydratase XII; carbonic anhydrase 12; CA-XII	Mouse	HEK293

HY-P72189

	*Coagulation Factor XII/F12 Protein, Pig (His)* F12 Coagulation factor XII; EC 3.4.21.38; Hageman factor; HAF; Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain	Pig	E. coli
	Coagulation factor XII (F12) is a serum glycoprotein that plays multiple roles in initiating blood coagulation, fibrinolysis, and the production of bradykinin and angiotensin. It is involved in these complex processes, including cleavage of prekallikrein to form kallikrein, which subsequently cleaves factor XII initially to α-factor XIIa and then, after trypsin cleavage, to β-factor XIIa. Coagulation Factor XII/F12 Protein, Pig (His) is the recombinant pig-derived Coagulation Factor XII/F12 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700599

	*Coagulation Factor XII/F12 Protein, Pig (P. pastoris, His)* F12 Coagulation factor XII; EC 3.4.21.38; Hageman factor; HAF; Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain	Pig	P. pastoris
	Coagulation factor XII (F12) is a serum glycoprotein that plays multiple roles in initiating blood coagulation, fibrinolysis, and the production of bradykinin and angiotensin. It is involved in these complex processes, including cleavage of prekallikrein to form kallikrein, which subsequently cleaves factor XII initially to α-factor XIIa and then, after trypsin cleavage, to β-factor XIIa. Coagulation Factor XII/F12 Protein, Pig (P. pastoris, His) is the recombinant pig-derived F12/Coagulation Factor XII, Pig, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71720

	CA12/Carbonic Anhydrase 12 Protein, Human (P.pastoris, His) CA 12; CA XII; CA12; Carbonic anhydrase XII; Carbonic dehydratase; CAXII; FLJ20151; HsT18816; T18816; Tumor antigen HOM RCC 3.1.3; Tumor antigen HOM-RCC-3.1.3	Human	P. pastoris
	CA12 (or carbonic anhydrase 12) plays a crucial role in the reversible hydration of carbon dioxide, catalyzing its conversion into bicarbonate ions and protons. This enzymatic activity is essential for key physiological processes, including regulating pH and maintaining acid-base balance. CA12/Carbonic Anhydrase 12 Protein, Human (P.pastoris, His) is the recombinant human-derived CA12/Carbonic Anhydrase 12 protein, expressed by P. pastoris , with N-6*His labeled tag.

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HY-P86796

	CA12 Antibody (YA6489) CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_HUMAN antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_HUMAN antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; FLJ20151 antibody; HsT18816 antibody; T18816 antibody; Tumor antigen HOM RCC 3.1.3 antibody; Tumor antigen HOM-RCC-3.1.3 antibody;	WB, ICC/IF, FC	Human
	CA12 Antibody (YA6489) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CA12.

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Cat. No.	Product Name		Classification

HY-159128

hCAIX-IN-21		Azide
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

HY-159129

hCAXII-IN-10		Azide
hCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a K_i value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases .

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