1672-88-4
1672-88-4
Chemical Structure
Furagin
Synonym(s): Furazidine; Furazidin
- CAS No.: 1672-88-4
- Formula:C10H8N4O5
- Molecular Weight:264.19
IUPAC Name: 1-(((1E,2E)-3-(5-nitrofuran-2-yl)allylidene)amino)imidazolidine-2,4-dione
InChIKey: DECBQELQORZLLP-UAIOPKHMSA-N
SMILES: O=C1NC(CN1/N=C/C=C/C2=CC=C(O2)[N+]([O-])=O)=O
Biological Activity: Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs)[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Furagin | 99.84% | Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs). | ||||||||||||||||||||
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Furagin (Standard) | ≥98% | Furagin (Standard) is the analytical standard of Furagin. This product is intended for research and analytical applications. Furagin (Furazidine) is an analogue of Nitrofurantoin (HY-A0090) and has antibacterial activity. Furagin also inhibits human carbonic anhydrases (Kis: 260 and 57 nM for hCA IX and XII, respectively). |
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Furagin-13C3 | Furagin-13C3 (Furazidine-13C3) is the 13C-labeled Furagin (HY-77036). Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 μg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs). | |||||||||||||||||||||
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References
- [1]. Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70. [Content Brief]
- [2]. Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30. [Content Brief]
- [3]. Pustenko A, et al. The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1011-1020. [Content Brief]
- [4]. Osterman IA, et al. Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors[J]. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7481-7489. [Content Brief]
- [5]. Sapegin A, et al. Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria. Biomedicines. 2022 Sep 6;10(9):2203. [Content Brief]
