hCAIX/XII-IN-6
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).
For research use only. We do not sell to patients.
- CAS No.: 3031666-31-3
- Formula: C26H23N3O6S4
- Molecular Weight:601.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA II 2950 nM (Ki) |
hCA IX 4.1 nM (Ki) |
hCA XII 7.7 nM (Ki) |
hCAIX/XII-IN-6 has inhibition activitr for human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively[1][1].
hCAIX/XII-IN-6 (150 μM) exhibits a weaker H2S releas[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:adjuvant-induced arthritis rat model[1]
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Dosage:1, 10, 30 mg/kg
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Administration:oral, single
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Result:Evoked an antihypersensitivity effect in a dose-dependent manner.
Reduced spontaneous pain in a dose-dependent manner with a peak of efficacy between 30 and 45 min.
Chemical Information
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CAS No. 3031666-31-3
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Molecular Weight 601.74
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Formula C26H23N3O6S4
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SMILES
O=C(N(CC1=CC=C([N+]([O-])=O)C=C1OC)CCC2=CC=C(S(=O)(N)=O)C=C2)C3=CC=C(C4=CSSC4=S)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX/XII-IN-6 Related Classifications
HY-151472 Related Classifications
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