12 Results for "

aconitase

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "aconitase" in MCE Product Catalog:

Cat. No.: HY-W016813
CAS No.: 4023-65-8
trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .
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Cat. No.: HY-W115721
CAS No.: 523-21-7
Synonyms: Sodium rhodizonate dibasic
Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures .
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Cat. No.: HY-135700
CAS No.: 19115-49-2
Purity:  ≥98.0%
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .
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Cat. No.: HY-131521
CAS No.: 89304-26-7
Synonyms: Oxalomalate trisodium
Research Areas:  

Cancer

Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .
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Cat. No.: HY-P74431
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACO2; aconitase; aconitase 2; Epididymis Secretory Sperm Binding Protein Li 284; Aconitate Hydratase, Mitochondrial; HEL-S-284; Citrate Hydro-Lyase; ICRD; ACONM; OCA8; aconitase 2, Mitochondrial; OPA9; Mitochondrial aconitase
Species:  
Source:  
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Cat. No.: HY-P74432
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACO2; aconitase; aconitase 2; Epididymis Secretory Sperm Binding Protein Li 284; Aconitate Hydratase, Mitochondrial; HEL-S-284; Citrate Hydro-Lyase; ICRD; ACONM; OCA8; aconitase 2, Mitochondrial; OPA9; Mitochondrial aconitase
Species:  
Source:  
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Cat. No.: HY-P74431A
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACO2; aconitase; aconitase 2; Epididymis Secretory Sperm Binding Protein Li 284; Aconitate Hydratase, Mitochondrial; HEL-S-284; Citrate Hydro-Lyase; ICRD; ACONM; OCA8; aconitase 2, Mitochondrial; OPA9; Mitochondrial aconitase
Species:  
Source:  
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Cat. No.: HY-P75560
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACO1; Cytosplasmic aconitase; Prev. IREB1; Soluble aconitase; IRP1; Epididymis Secretory Sperm Binding Protein; Iron-Responsive Element-Binding Protein 1; Epididymis Luminal Protein 60; Cytoplasmic Aconitate Hydratase; Cytoplasmic aconitase; Iron Regulato
Species:  
Source:  
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Cat. No.: HY-P82406
Synonyms: Aconitate hydratase; mitochondrial; aconitase; Citrate hydro-lyase

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P83105
Synonyms: ACO1; IREB1; Cytoplasmic aconitate hydratase; aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P75559
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Aconitate hydratase B; EC:4.2.1.3; ACN; aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; EC:4.2.1.99; Iron-responsive protein-like; IRP-like; RNA-binding protein
Species:  
Source:  
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Cat. No.: HY-P811169
Synonyms: IREB1, ACO1, Cytoplasmic aconitate hydratase, aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, Iron-responsive element-binding protein 1, IRP1, IRE-BP 1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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