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Results for "

aconitase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcineurin (1) DNA/RNA Synthesis (1) HMG-CoA Reductase (HMGCR) (1) Isocitrate Dehydrogenase (IDH) (1) Parasite (1) Ras (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W016813

trans-Aconitic acid	Parasite	Infection
trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .

HY-W115721

Rhodizonic acid disodium Sodium rhodizonate dibasic	Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Others
Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits *Aconitase* activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures .

HY-135700

Mevalonolactone	Calcineurin Ras HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (K_a = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a *aconitase* and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

Cat. No.	Product Name	Type

HY-W115721

Rhodizonic acid disodium Sodium rhodizonate dibasic	Biochemical Assay Reagents
Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits *Aconitase* activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures .

Rhodizonic acid disodium

Sodium rhodizonate dibasic

Biochemical Assay Reagents

Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W016813

trans-Aconitic acid	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer Source Classification	Parasite
trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .

HY-135700

Mevalonolactone	Structural Classification Microorganisms Other Phenylpropanoids Phenylpropanoids Source Classification	Calcineurin Ras HMG-CoA Reductase (HMGCR)
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (K_a = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .

Species:	Virus (1) Human (2) Mouse (2)
Tag:	His (4) Tag Free (1) GST (3)
Source:	Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74432

	Aconitase 2/ACO2 Protein, Human (sf9, His-GST) Aconitate hydratase; aconitase; ACO2	Human	Sf9 insect cells
	Aconitase 2/ACO2 Protein, an enzyme, plays a vital role in the tricarboxylic acid cycle and energy production. Dysregulation of Aconitase 2/ACO2 Protein has been associated with mitochondrial dysfunction and oxidative stress. Targeting Aconitase 2/ACO2 Protein may provide potential therapeutic strategies by regulating energy metabolism, reducing oxidative damage, and improving mitochondrial function. Aconitase 2/ACO2 Protein, Human (sf9, His-GST) is the recombinant human-derived Aconitase 2/ACO2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74431A

	Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST) Aconitate hydratase; aconitase; ACO2	Mouse	Sf9 insect cells
	Aconitase 2 (ACO2) protein catalyzes the isomerization of citric acid to isocitrate through the intermediate aconitate, playing a crucial role in cellular metabolism. This enzyme activity is a key step in the tricarboxylic acid (TCA) cycle, a central pathway for energy production and generation of metabolic intermediates. Aconitase 2/ACO2 Protein, Mouse (sf9, His, GST) is the recombinant mouse-derived Aconitase 2/ACO2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74431

	Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST, solution) Aconitate hydratase; aconitase; ACO2	Mouse	Sf9 insect cells
	Aconitase 2 (ACO2) protein catalyzes the isomerization of citric acid to isocitrate through the intermediate aconitate, playing a crucial role in cellular metabolism. This enzyme activity is a key step in the tricarboxylic acid (TCA) cycle, a central pathway for energy production and generation of metabolic intermediates. Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST, solution) is the recombinant mouse-derived Aconitase 2/ACO2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75560

	Aconitase 1/ACO1 Protein, Human (sf9, His) Cytoplasmic aconitate hydratase; aconitase; IRP1; IRE-BP 1; ACO1; IREB1	Human	Sf9 insect cells
	The ACO1 protein is a bifunctional iron sensor that dynamically adapts to cellular iron levels. Under conditions of iron deficiency, it is converted to mRNA binding and regulates iron-related gene expression. Aconitase 1/ACO1 Protein, Human (sf9, His) is the recombinant human-derived Aconitase 1/ACO1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P75559

	acnB Protein, E. coli Aconitate hydratase B; ACN; aconitase; RNA-binding protein; acnB; yacI; yacJ	Virus	E. coli
	The acnB protein coordinates short-chain fatty acid catabolism through the TCA pathway and 2-methylcitric acid cycle I, demonstrating catalytic versatility. It is involved in the reversible isomerization of citric acid to isocitrate and the hydration of 2-methyl-cis-aconitic acid. acnB Protein, E. coli is the recombinant Virus-derived acnB protein, expressed by E. coli , with tag free.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82406

	Aconitase 2 Antibody (YA2151) Aconitate hydratase; mitochondrial; aconitase; Citrate hydro-lyase	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Aconitase 2 Antibody (YA2151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aconitase 2.

HY-P83105

	Aconitase 1 Antibody (YA2850) ACO1; IREB1; Cytoplasmic aconitate hydratase; aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1	WB, ICC/IF	Human, Mouse, Rat
	Aconitase 1 Antibody (YA2850) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aconitase 1.

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aconitase

Inhibitors & Agonists

Biochemical Assay Reagents

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Recombinant Proteins

Antibodies

Natural
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