4023-65-8
Chemical Structure
trans-Aconitic acid
- CAS No.: 4023-65-8
- Formula:C6H6O6
- Molecular Weight:174.11
IUPAC Name: (E)-prop-1-ene-1,2,3-tricarboxylic acid
InChIKey: GTZCVFVGUGFEME-HNQUOIGGSA-N
SMILES: O=C(O)/C=C(CC(O)=O)/C(O)=O
Biological Activity: trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar)[1][2][3][4].
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trans-Aconitic acid | 99.74% | trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar). | ||||||||||||||||||||
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trans-Aconitic acid (Standard) | 99.76% | trans-Aconitic acid (Standard) is the analytical standard of trans-Aconitic acid. This product is intended for research and analytical applications. trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase. | ||||||||||||||||||||
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- [1]. Misra S, et al. Evaluation of antileishmanial activity of trans-aconitic acid. Biochem Med Metab Biol. 1989;42(3):171-178. [Content Brief]
- [2]. Kar S, et al. Experimental visceral leishmaniasis: role of trans-aconitic acid in combined chemotherapy. Antimicrob Agents Chemother. 1993;37(11):2459-2465. [Content Brief]
- [3]. Montoya G, et al. Quantitation of trans-aconitic acid in different stages of the sugar-manufacturing process. J Agric Food Chem. 2014;62(33):8314-8318. [Content Brief]
- [4]. Bortolo TDSC, et al. Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max. Plant Physiol Biochem. 2018;132:490-496. [Content Brief]
