523-21-7
Chemical Structure
Rhodizonic acid disodium
Synonym(s): Sodium rhodizonate dibasic
- CAS. Nr.: 523-21-7
- Formula:C6Na2O6
- Molecular Weight:214.04
IUPAC Name: sodium 3,4,5,6-tetraoxocyclohex-1-ene-1,2-bis(olate)
InChIKey: SXWPCWBFJXDMAI-UHFFFAOYSA-L
SMILES: O=C(C(O[Na])=C(C1=O)O[Na])C(C1=O)=O
Biological Activity: Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures[1][2].
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Rhodizonic acid disodium | Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures. | |||||||||||||||||||||
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References
- [1]. Murakami K, et al. Prooxidant action of rhodizonic acid: transition metal-dependent generation of reactive oxygen species causing the formation of 8-hydroxy-2'-deoxyguanosine formation in DNA. Toxicol In Vitro. 2006;20(6):910-914. [Content Brief]
- [2]. Huskey DA, et al. Use of rhodizonic acid for rapid detection of root border cell trapping of lead and reversal of trapping with DNase. Appl Plant Sci. 2019;7(4):e01240. Published 2019 Apr 12. [Content Brief]
