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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
alkylating reagent
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "alkylating reagent" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-W004702
CAS No.: 66-27-3
Cat. No.: HY-D0843S
CAS No.: 360768-37-2
Synonyms: NEM-d5
Synonyms: 4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate; PNBM
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate) is an alkylating reagent. p-Nitrobenzyl mesylate alkylates thiophosphorylated serine, threonine, tyrosine residues and cysteine thiols, without modifying hydroxyl, amino or carboxylic acid functional groups. p-Nitrobenzyl mesylate generates thiophosphate epitopes on thiophosphorylated substrate proteins for recognition by thiophosphate-specific antibodies. p-Nitrobenzyl mesylate facilitates the identification and purification of kinase substrates. p-Nitrobenzyl mesylate is applicable to studies related to cerebral ischemia-reperfusion injury .
Target:
Research Areas:
DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .
Cat. No.: HY-76667
CAS No.: 83948-53-2
Research Areas:
3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13 .
Cat. No.: HY-W004702R
CAS No.: 66-27-3
Cat. No.: HY-W004131
CAS No.: 4916-55-6
Target:
Research Areas:
3-Bromomethylpyridine hydrobromide is an intermediate that can be used for the preparation of 1,5-disubstituted tetrazole-based P2X7 antagonists .
Cat. No.: HY-Y0643
CAS No.: 18997-19-8
Cat. No.: HY-W615327
CAS No.: 899452-51-8
Target:
Research Areas:
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
Cat. No.: HY-W004702S
CAS No.: 91419-94-2
Synonyms: METHYLMETHANE SULPHONATE-d3
Cat. No.: HY-W007502
CAS No.: 6959-47-3
Synonyms: Picolyl chloride hydrochloride
Cat. No.: HY-151738
CAS No.: 1935981-35-3
Target:
Research Areas:
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W012890
CAS No.: 38291-82-6
Synonyms: Valeric acid hydrazide
Target:
Research Areas:
Pentanehydrazide (Valeric acid hydrazide) is a biochemical reagent that can act as an effective alkylating agent in the copper-catalyzed oxidative cyclization of N-arylacrylamides and participate in the tandem acylation reaction .
Cat. No.: HY-W105731
CAS No.: 16355-92-3
Synonyms: Decamethylene diiodide
Target:
Research Areas:
1,10-Diiododecane (Decamethylene diiodide) serves as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and acts as an alkylating agent in the synthesis of both symmetrical and unsymmetrical bis-cryptophanes, in addition to being utilized for the production of decane at a temperature of 20°C.
Cat. No.: HY-W800828
CAS No.: 2512227-27-7
Target:
Research Areas:
Iodoacetamido-PEG3-NHS ester is a PEG reagent containing an Iodoacetamide group and a Boc-protected amino group. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Cat. No.: HY-W190952
CAS No.: 2055047-19-1
Target:
Research Areas:
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
Cat. No.: HY-W190947
CAS No.: 1698019-88-3
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Research Areas:
Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.
Cat. No.: HY-W800627
CAS No.: 2363757-66-6
Target:
Research Areas:
Bis-sulfone-PEG8-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
