39628-94-9
Chemical Structure
p-Nitrobenzyl mesylate
Synonym(s): 4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate; PNBM
- CAS. Nr.: 39628-94-9
- Formula:C8H9NO5S
- Molecular Weight:231.23
IUPAC Name: 4-nitrobenzyl methanesulfonate
InChIKey: QZIYKAFPHRTIAI-UHFFFAOYSA-N
SMILES: CS(OCC1=CC=C(C=C1)[N+]([O-])=O)(=O)=O
Biological Activity: p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate) is an alkylating reagent. p-Nitrobenzyl mesylate alkylates thiophosphorylated serine, threonine, tyrosine residues and cysteine thiols, without modifying hydroxyl, amino or carboxylic acid functional groups. p-Nitrobenzyl mesylate generates thiophosphate epitopes on thiophosphorylated substrate proteins for recognition by thiophosphate-specific antibodies. p-Nitrobenzyl mesylate facilitates the identification and purification of kinase substrates. p-Nitrobenzyl mesylate is applicable to studies related to cerebral ischemia-reperfusion injury[1][2][3].
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p-Nitrobenzyl mesylate | 98.78% | p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate) is an alkylating reagent. p-Nitrobenzyl mesylate alkylates thiophosphorylated serine, threonine, tyrosine residues and cysteine thiols, without modifying hydroxyl, amino or carboxylic acid functional groups. p-Nitrobenzyl mesylate generates thiophosphate epitopes on thiophosphorylated substrate proteins for recognition by thiophosphate-specific antibodies. p-Nitrobenzyl mesylate facilitates the identification and purification of kinase substrates. p-Nitrobenzyl mesylate is applicable to studies related to cerebral ischemia-reperfusion injury. | ||||||||||||||||||||
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References
- [1]. Allen JJ, et al. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun;4(6):511-6. [Content Brief]
- [2]. Kumar V, et al. Generation and characterization of ATP analog-specific protein kinase Cδ. J Biol Chem. 2015;290(4):1936-1951. [Content Brief]
- [3]. Leissing F, et al. Substrate thiophosphorylation by Arabidopsis mitogen-activated protein kinases. BMC Plant Biol. 2016;16:48. Published 2016 Feb 24. [Content Brief]
