2-(Chloromethyl)pyridine hydrochloride
Based on 1 Customer Validation
2-(Chloromethyl)pyridine (Picolyl chloride) hydrochloride is an alkylating agent that can be used in organic synthesis reactions.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 6959-47-3
- Formula: C6H7Cl2N
- Molecular Weight:164.03
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-(Chloromethyl)pyridine hydrochloride can introduce pyridine groups in the reaction with calix[4]arenes, and the conformation of the product is affected by the base used[1].
2-(Chloromethyl)pyridine hydrochloride is an electrophile used in the alkylation reaction of p-tert-butylcalix[5]arene, which can generate a variety of pyridinyl homologues[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6959-47-3
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Appearance Solid
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Molecular Weight 164.03
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Formula C6H7Cl2N
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Color Yellow to brown
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SMILES
ClCC1=CC=CC=N1.Cl
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Synonyms
Picolyl chloride hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (304.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (614 KB)
- English - EN (614 KB)
- Français - FR (614 KB)
- Deutsch - DE (614 KB)
- Norwegian - NO (614 KB)
- Español - ES (614 KB)
- Swedish - SV (614 KB)
- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0964 mL | 30.4822 mL | 60.9645 mL | 152.4111 mL |
| 5 mM | 1.2193 mL | 6.0964 mL | 12.1929 mL | 30.4822 mL | |
| 10 mM | 0.6096 mL | 3.0482 mL | 6.0964 mL | 15.2411 mL | |
| 15 mM | 0.4064 mL | 2.0321 mL | 4.0643 mL | 10.1607 mL | |
| 20 mM | 0.3048 mL | 1.5241 mL | 3.0482 mL | 7.6206 mL | |
| 25 mM | 0.2439 mL | 1.2193 mL | 2.4386 mL | 6.0964 mL | |
| 30 mM | 0.2032 mL | 1.0161 mL | 2.0321 mL | 5.0804 mL | |
| 40 mM | 0.1524 mL | 0.7621 mL | 1.5241 mL | 3.8103 mL | |
| 50 mM | 0.1219 mL | 0.6096 mL | 1.2193 mL | 3.0482 mL | |
| 60 mM | 0.1016 mL | 0.5080 mL | 1.0161 mL | 2.5402 mL | |
| 80 mM | 0.0762 mL | 0.3810 mL | 0.7621 mL | 1.9051 mL | |
| 100 mM | 0.0610 mL | 0.3048 mL | 0.6096 mL | 1.5241 mL |
2-(Chloromethyl)pyridine hydrochloride Related Classifications
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