360768-37-2
360768-37-2
Chemical Structure
N-Ethylmaleimide-d5
Synonym(s): NEM-d5
- CAS No.: 360768-37-2
- Formula:C6H2D5NO2
- Molecular Weight:130.16
IUPAC Name: 1-(ethyl-d5)-1H-pyrrole-2,5-dione
InChIKey: HDFGOPSGAURCEO-ZBJDZAJPSA-N
SMILES: O=C(C=C1)N(C([2H])([2H])C([2H])([2H])[2H])C1=O
Biological Activity: N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
N-Ethylmaleimide-d5 | 99.84% | N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Ethylmaleimide (Standard) | ≥98% | Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Ethylmaleimide | 99.59% | N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9. [Content Brief]
- [3]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.
