40 Results for "

antigen-presenting cells

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "antigen-presenting cells" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-112758
CAS No.: 1190197-97-7
Purity:  99.88%
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
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8
8 Cited Publications
Cat. No.: HY-101092
CAS No.: 141256-04-4
Purity:  99.67%
Synonyms: Stimulon
QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .
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2
2 Cited Publications
Cat. No.: HY-K0353

MCE Human CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

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1
1 Cited Publications
Cat. No.: HY-168374
CAS No.: 1829524-73-3
DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume .
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1
1 Cited Publications
Cat. No.: HY-P99742
CAS No.: 2055640-86-1
Synonyms: ADC-1013; JNJ-64457107; Vanalimab

Target:  

TNF Receptor

Research Areas:  

Cancer

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment .
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1
1 Cited Publications
Cat. No.: HY-NP159
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .
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1
1 Cited Publications
Cat. No.: HY-P5623
CAS No.: 115136-25-9
Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29
RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery .
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1 Cited Publications
Cat. No.: HY-P99414
CAS No.: 1523164-68-2
Synonyms: AMG 557
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .
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1
1 Cited Publications
Cat. No.: HY-P5623B
Synonyms: RVG29 TFA; RDP TFA; Rabies Virus Glycoprotein-29 TFA
Target:  

Bacterial

Research Areas:  

Infection

RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .
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Cat. No.: HY-NP141
Synonyms: 4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin
NP-BSA (4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin) is an antigen-adjuvant conjugate of 4-Hydroxy-3-nitrophenylacetyl (NP) conjugated to bovine serum albumin (BSA), which is an immune complex. NP-BSA is taken up, processed, and presented by antigen-presenting cells to stimulate T-cell proliferation and the production of antigen-specific antibodies. NP-BSA can be used in the research of immunological vaccines .
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Cat. No.: HY-163028
CAS No.: 459789-75-4
Target:  

Tim3

Research Areas:  

Cancer

ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .
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Cat. No.: HY-P99049
CAS No.: 2305607-45-6
Synonyms: APX005M; APX005M; EPI-0050

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma .
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Cat. No.: HY-165126
CAS No.: 9050-67-3
Synonyms: SPG
Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune. Schizophyllan improves mitochondrial function and protects against metabolic liver injury by activating the SIRT3 pathway. Schizophyllan inhibits osteoclastogenesis and promotes osteoblast differentiation by suppressing the phosphorylation of JNK/p38, as well as downregulating PGC1β/PPARγ, c-Fos and NFATc1. Recognized via Dectin-1, schizophyllan enables precise delivery of oligonucleotide drugs and antigens to antigen-presenting cells, thus holding great potential in the treatment of inflammatory diseases and vaccine development .
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Cat. No.: HY-P99845
CAS No.: 2245953-10-8
Synonyms: MEDI 4920; VIB 4920

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Dazodalibep (MEDI 4920; VIB 4920) is a non-antibody fusion protein that targets CD40L. Dazodalibep inhibits the co-stimulatory signals between immune cells (such as T cells, B cells, and antigen-presenting cells), thereby enabling the inhibition of a broader range of cellular and humoral responses. Dazodalibep can be used for research on rheumatoid arthritis and Sjögren's syndrome .
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Cat. No.: HY-153205
Research Areas:  

Inflammation/Immunology

Aluminum hydroxide adjuvant is a vaccine aluminum adjuvant. The aluminum content is 9-11 mg/mL. Aluminum hydroxide adjuvant induces the differentiation of macrophages into a new type of mature, specialized antigen-presenting cells in vitro . It has a strong adsorption capacity for negatively charged antigens, a significant sustained-release effect, no stress response, high safety, and can effectively induce immune responses in the body. It is suitable for various veterinary vaccines, including inactivated vaccines or gene-engineered subunit vaccines for bacterial and viral diseases of livestock and poultry. It is suitable for various veterinary vaccines, including inactivated vaccines or gene-engineered subunit vaccines for bacterial and viral diseases of livestock and poultry.
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Cat. No.: HY-112307A
CAS No.: 124011-52-5
Purity:  99.97%
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .
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Cat. No.: HY-151509
CAS No.: 2412492-07-8
Purity:  95.64%
Target:  

Liposome

Research Areas:  

Cancer

A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma. .
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Cat. No.: HY-P2455
CAS No.: 137856-41-8
Synonyms: Listeriolysin O (91-99)
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .
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Cat. No.: HY-P99928
CAS No.: 2574508-57-7
Synonyms: MK 7110; CD24 Fc

Research Areas:  

Cancer

Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome .
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Cat. No.: HY-148776
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a degradable amphiphilic polymer nanocarrier of poly (lactic acid-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) serves as a core polymer for nanoparticle synthesis, and also acts as a nanoparticle component for site-specific antibody conjugation to construct artificial antigen-presenting cells. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is applicable for drug delivery-related research .
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