1523164-68-2
Chemical Structure
Prezalumab
Synonym(s): AMG 557
- CAS No.: 1523164-68-2
- Formula:N/A
- Molecular Weight:(145.5 kDa)
IUPAC Name: isopropyl N-(tert-butoxycarbonyl)-O-tosyl-L-serinate
SMILES: [Prezalumab]
Biological Activity: Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002)[1][2].
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Prezalumab | 99.41% | Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). | ||||||||||||||||||||
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- [1]. Dillon SR, et al. Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101). Arthritis Rheumatol. 2023 Aug;75(8):1344-1356. [Content Brief]
- [2]. Cheng LE, et al. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 Jul;70(7):1071-1076. [Content Brief]
Keywords
