Search Result
Results for "
bioorthogonal labeling
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-133870
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ITalk
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Fluorescent Dye
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Inflammation/Immunology
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Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D2171A
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Fluorescent Dye
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Others
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AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
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- HY-W784030
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Amino Acid Derivatives
Biochemical Assay Reagents
Fluorescent Dye
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Others
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N-TCO-L-lysine is a non-canonical amino acid. N-TCO-L-lysine contains a trans-cyclooctene (TCO) bioorthogonal reactive linker. N-TCO-L-lysine undergoes a bioorthogonal click reaction with SiR-Tz to enable fluorescent labeling of endogenously expressed proteins with site-specific incorporation. When used in combination with SiR-Tz, N-TCO-L-lysine allows super-resolution and live-cell imaging of endogenous proteins .
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- HY-114354
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BOD FL alkyne
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Fluorescent Dye
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Inflammation/Immunology
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BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
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- HY-D2171
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Fluorescent Dye
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Others
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AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
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- HY-W048513
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DNA/RNA Synthesis
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Cancer
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7-Deaza-2'-deoxyadenosine is an isosteric dATP analog of 2'-deoxyadenosine. 7-Deaza-2'-deoxyadenosine is recognized by various DNA polymerases and incorporated into DNA strands as a substrate. 7-Deaza-2'-deoxyadenosine undergoes a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules, enabling site-specific labeling of DNA, surface antibody immobilization and intracellular fluorescent labeling. 7-Deaza-2'-deoxyadenosine reduces the DNA curvature of d(A6)·d(T6) fragments and the stability of DNA/RNA double helices, and leads to decreased antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine finds application in the research field of SV40 T Antigen-related cancers .
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- HY-177764
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Amino Acid Derivatives
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Others
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Tet-v2.0-ethyl is a tetrazine non-canonical amino acid. Tet-v2.0-ethyl can stably exist within living cells without being degraded, enabling in situ labeling of intracellular biomolecules. Tet-v2.0-ethyl is mainly used as a bioorthogonal labeling tool compound .
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- HY-W415798
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Endogenous Metabolite
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Others
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Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
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- HY-148958
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- HY-D2926
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BG-Tz; SNAP-Tetrazine
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Biochemical Assay Reagents
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Others
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BG-Tetrazine (BG-Tz; SNAP-Tetrazine) is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .
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- HY-112944A
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CMP-NeuNAz sodium
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Sialyltransferase
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Infection
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CMP-SiaNAz (CMP-NeuNAz) sodium is a sialic acid nucleotide sugar derivative. CMP-SiaNAz sodium is integrated into the glycosidic chain through the action of STs in the Golgi apparatus, forming SiaNAz substances. CMP-SiaNAz sodium can serve as a substrate for bacterial-derived sialic acid transferases and is used for chemical enzymatic labeling and imaging of cell surface glycosides .
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- HY-D2989
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SNAP-NH2-Ac-N3
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Biochemical Assay Reagents
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Others
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BG-NH2-Ac-N3 (SNAP-NH2-Ac-N3) is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .
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- HY-W800838
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Fluorescent Dye
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Cancer
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BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.
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- HY-177764A
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Amino Acid Derivatives
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Others
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Tet-v2.0-ethyl hydrochloride is a tetrazine non-canonical amino acid. Tet-v2.0-ethyl hydrochloride can stably exist within living cells without being degraded, enabling in situ labeling of intracellular biomolecules. Tet-v2.0-ethyl hydrochloride is mainly used as a bioorthogonal labeling tool compound .
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- HY-D2955
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CLIP-AZIDE
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Biochemical Assay Reagents
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Others
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BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .
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- HY-D2925
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dTCO-SNAP
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Biochemical Assay Reagents
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Others
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dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .
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- HY-173578
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Biochemical Assay Reagents
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Others
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N-(2-Poc-ethyl)betulin amide is a triterpenoid with antiviral and antitumor activities. N-(2-Poc-ethyl)betulin amide contains a Poc (prop-2-yn-1-yloxycarbonyl) alkynyl protecting group, which allows for bioorthogonal reactions (such as click chemistry) and is used for targeted delivery and fluorescent labeling .
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- HY-D2941
-
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SNAP-AF
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Fluorescent Dye
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Others
|
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .
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- HY-D2930
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SNAP-SS-SulfoCy5
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Fluorescent Dye
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Others
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BG-SS-SulfoCy5 (SNAP-SS-SulfoCy5) is a SulfoCy5-labeled SNAP tag fluorescent probe, linked by a disulfide bond. BG-SS-SulfoCy5 combines the specific recognition of SNAP-tag, the cleavability of disulfide bond, and the excellent optical properties of SulfoCy5. BG-SS-SulfoCy5 can be used for tracking the internalization of cell surface proteins and multiple labeling experiments .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D2171A
-
|
|
Fluorescent Dyes
|
|
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
|
-
- HY-114354
-
|
BOD FL alkyne
|
Fluorescent Dyes
|
|
BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
|
-
- HY-D2171
-
|
|
Fluorescent Dyes
|
|
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
|
-
- HY-148958
-
|
|
Fluorescent Dyes
|
SNAP-Biotin is a biotin-labeled SNAP tag probe. SNAP-Biotin can be used for protein biotinylation .
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- HY-D2926
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BG-Tz; SNAP-Tetrazine
|
Fluorescent Dyes
|
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BG-Tetrazine (BG-Tz; SNAP-Tetrazine) is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .
|
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- HY-D2989
-
|
SNAP-NH2-Ac-N3
|
Fluorescent Dyes
|
BG-NH2-Ac-N3 (SNAP-NH2-Ac-N3) is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .
|
-
- HY-W800838
-
|
|
Fluorescent Dyes
|
|
BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.
|
-
- HY-D2955
-
|
CLIP-AZIDE
|
Fluorescent Dyes
|
|
BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .
|
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- HY-D2925
-
|
dTCO-SNAP
|
Fluorescent Dyes
|
|
dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .
|
-
- HY-D2941
-
|
SNAP-AF
|
Fluorescent Dyes
|
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .
|
-
- HY-D2930
-
|
SNAP-SS-SulfoCy5
|
Fluorescent Dyes
|
|
BG-SS-SulfoCy5 (SNAP-SS-SulfoCy5) is a SulfoCy5-labeled SNAP tag fluorescent probe, linked by a disulfide bond. BG-SS-SulfoCy5 combines the specific recognition of SNAP-tag, the cleavability of disulfide bond, and the excellent optical properties of SulfoCy5. BG-SS-SulfoCy5 can be used for tracking the internalization of cell surface proteins and multiple labeling experiments .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W048513
-
|
|
Biochemical Assay Reagents
|
|
7-Deaza-2'-deoxyadenosine is an isosteric dATP analog of 2'-deoxyadenosine. 7-Deaza-2'-deoxyadenosine is recognized by various DNA polymerases and incorporated into DNA strands as a substrate. 7-Deaza-2'-deoxyadenosine undergoes a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules, enabling site-specific labeling of DNA, surface antibody immobilization and intracellular fluorescent labeling. 7-Deaza-2'-deoxyadenosine reduces the DNA curvature of d(A6)·d(T6) fragments and the stability of DNA/RNA double helices, and leads to decreased antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine finds application in the research field of SV40 T Antigen-related cancers .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-133870
-
|
ITalk
|
|
Alkynes
|
|
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D2171A
-
|
|
|
DBCO
|
|
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
|
-
- HY-D2171
-
|
|
|
DBCO
|
|
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .
|
-
- HY-W415798
-
|
|
|
Alkynes
|
|
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
|
-
- HY-D2926
-
|
BG-Tz; SNAP-Tetrazine
|
|
Tetrazine
|
|
BG-Tetrazine (BG-Tz; SNAP-Tetrazine) is a SNAP tag substrate that contains a methyl tetrazine group. BG-Tetrazine can specifically covalently label the target protein of the intracellular SNAP-tag fusion. The tetrazine group it carries can rapidly and efficiently undergo a bioorthogonal reaction with functional groups such as trans cyclooctene (TCO), thereby enabling multiple labeling, functionalization or enrichment of proteins. BG-Tetrazine can be applied in click chemistry .
|
-
- HY-D2989
-
|
SNAP-NH2-Ac-N3
|
|
Azide
|
BG-NH2-Ac-N3 (SNAP-NH2-Ac-N3) is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .
|
-
- HY-D2955
-
|
CLIP-AZIDE
|
|
Azide
|
|
BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W048513
-
|
|
|
Nucleoside Analogs
Adenosine
|
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7-Deaza-2'-deoxyadenosine is an isosteric dATP analog of 2'-deoxyadenosine. 7-Deaza-2'-deoxyadenosine is recognized by various DNA polymerases and incorporated into DNA strands as a substrate. 7-Deaza-2'-deoxyadenosine undergoes a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules, enabling site-specific labeling of DNA, surface antibody immobilization and intracellular fluorescent labeling. 7-Deaza-2'-deoxyadenosine reduces the DNA curvature of d(A6)·d(T6) fragments and the stability of DNA/RNA double helices, and leads to decreased antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine finds application in the research field of SV40 T Antigen-related cancers .
|
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