302795-84-2
Chemical Structure
BODIPY FL alkyne
Synonym(s): BOD FL alkyne
- CAS No.: 302795-84-2
- Formula:C17H18BF2N3O
- Molecular Weight:329.15
IUPAC Name: 3-(5,5-difluoro-7,9-dimethyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(prop-2-yn-1-yl)propanamide
InChIKey: MNNMNNMEHKMADE-UHFFFAOYSA-N
SMILES: O=C(NCC#C)CCC1=CC=C(C=C(C(C)=C2)[N]3=C2C)[N-]1[B+3]3([F-])[F-]
Biological Activity: BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease[1][2][3].
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BODIPY FL alkyne | 98.60% | BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease. | ||||||||||||||||||||
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- [1]. Vidyakina A A, et al. Key role of cycloalkyne nature in alkyne-dye reagents for enhanced specificity of intracellular imaging by bioorthogonal bioconjugation[J]. Organic & Biomolecular Chemistry, 2024, 22(37): 7637-7642.
- [2]. Antina E, et al. BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment. Molecules. 2022;27(4):1396. Published 2022 Feb 18. [Content Brief]
- [3]. Reese AE, et al. Inserting "OFF-to-ON" BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells. ACS Cent Sci. 2023;10(1):143-154. Published 2023 Dec 20. [Content Brief]
Keywords
