471918-16-8
Chemical Structure
SNAP-Biotin
- CAS No.: 471918-16-8
- Formula:C29H39N9O4S
- Molecular Weight:609.74
IUPAC Name: N-(4-(((2-amino-7H-purin-6-yl)oxy)methyl)benzyl)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamide
InChIKey: KATDWLJFCBSLAZ-HFMPRLQTSA-N
SMILES: NC1=NC(OCC(C=C2)=CC=C2CNC(CCCCCNC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O)=C5C(N=CN5)=N1
Biological Activity: SNAP-Biotin is a cell-permeable SNAP-tag-targeted labeling reagent. SNAP-Biotin undergoes an irreversible covalent reaction with SNAP-tag to transfer biotin to the tag. SNAP-Biotin enables the detection of SNAP-tag fusion proteins via a streptavidin-HRP immunoblotting system and achieves biotinylation of SNAP-tag fusion proteins. SNAP-Biotin is applicable to triple-negative breast cancer-related research[1][2][3][4].
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SNAP-Biotin | SNAP-Biotin is a cell-permeable SNAP-tag-targeted labeling reagent. SNAP-Biotin undergoes an irreversible covalent reaction with SNAP-tag to transfer biotin to the tag. SNAP-Biotin enables the detection of SNAP-tag fusion proteins via a streptavidin-HRP immunoblotting system and achieves biotinylation of SNAP-tag fusion proteins. SNAP-Biotin is applicable to triple-negative breast cancer-related research. | |||||||||||||||||||||
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References
- [1]. Stoops EH, et al. SNAP-tag to monitor trafficking of membrane proteins in polarized epithelial cells. Methods in molecular biology (Clifton, N.J.). 2014;1174:171-82. [Content Brief]
- [2]. Wilhelm J, et al. Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry. 2021 Aug 24;60(33):2560-2575. [Content Brief]
- [3]. Xu X, et al. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions. Nat Commun. 2022 May 6;13(1):2514. doi: 10.1038/s41467-022-30298-4. Erratum in: Nat Commun. 2022 Jun 20;13(1):3533.
- [4]. Steinebrunner I, et al. HCC1, the Arabidopsis homologue of the yeast mitochondrial copper chaperone SCO1, is essential for embryonic development. Journal of experimental botany. 2011 Jan;62(1):319-30.
