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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
155 Results for "
coagulation factor
" in MedChemExpress (MCE) Product Catalog:
Products (155)
155 Results for "coagulation factor" in MCE Product Catalog:
64
64 Publications Verification
Synonyms: Sodium heparin; Sodium heparinate
Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.
20
20 Cited Publications
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
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11 Cited Publications
Cat. No.: HY-P1929
CAS No.: 128270-60-0
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11
11 Cited Publications
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10
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Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research .
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Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research .
10
10 Cited Publications
Synonyms: DU-176b monohydrate
Research Areas:
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research .
9
9 Cited Publications
Cat. No.: HY-114164H
CAS No.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Research Areas:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
7
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Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM .
4
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Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .
3
3 Cited Publications
Synonyms: Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)
Research Areas:
Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa .
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1
1 Cited Publications
Cat. No.: HY-P4245
CAS No.: 88546-74-1
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1
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1
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1
1 Cited Publications
Cat. No.: HY-P701216
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F2; coagulation factor II (Thrombin); coagulation factor II, Thrombin; Prothrombin B-Chain; Prothrombin; F2 Protein; Prepro-coagulation factor II; RPRGL2; coagulation factor II; THPH1; Thrombin factor II; PT
Species:
Human
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P70231
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; coagulation factor IX; Coagulant factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; Hemophilia B; Plasma Thromboplastin Component; factor IX F9; Christmas factor; factor IX; PTC; factor 9; Truncated coagulation Fa
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P74238
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F13B; Fibrin-Stabilizing factor B Subunit; coagulation factor XIII B Chain; Transglutaminase B Chain; FXIIIB; Alternative Protein F13B; Protein-Glutamine Gamma-Glutamyltransferase B Chain; TGase; coagulation factor XIII, B Polypeptide
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77227
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI; EPI; Prev. LACI; Tissue factor Pathway Inhibitor (Lipoprotein-Associated coagulation Inhibitor); Extrinsic Pathway Inhibitor; Lipoprotein-Associated coagulation Inhibitor; TFPI1; Anti-Convertin; Tissue factor Pathway Inhibitor; TFI
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
