39 Results for "

convertases

" in MedChemExpress (MCE) Product Catalog:
Products (39)

39 Results for "convertases" in MCE Product Catalog:

6
Hexa-D-arginine
Hexa-D-arginine
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6 Publications Verification
Cat. No.: HY-P1028
CAS No.: 673202-67-0
Synonyms: Furin Inhibitor II
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
6
PF-06446846 hydrochloride
PF-06446846 hydrochloride
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6 Publications Verification
Cat. No.: HY-120088A
CAS No.: 1632250-50-0
Purity:  99.44%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34 .
6
PF-06446846
PF-06446846
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6 Publications Verification
Cat. No.: HY-120088
CAS No.: 1632250-49-7
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .
6
Hexa-D-arginine TFA
Hexa-D-arginine TFA
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6 Publications Verification
Cat. No.: HY-P1028A
CAS No.: 958204-56-3
Synonyms: Furin Inhibitor II TFA
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
3
SBC-115076
SBC-115076
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3 Cited Publications
Cat. No.: HY-12402
CAS No.: 489415-96-5
Purity:  99.28%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism .
1
SBC-110736
SBC-110736
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1 Cited Publications
Cat. No.: HY-101832
CAS No.: 1629166-02-4
Purity:  99.55%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease Metabolic Disease

SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1 .
1
Complement C5-IN-1
Complement C5-IN-1
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1 Cited Publications
Cat. No.: HY-128342
CAS No.: 2365402-67-9
Purity:  99.14%
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
1
Boc-Leu-Gly-Arg-AMC
Boc-Leu-Gly-Arg-AMC
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1 Cited Publications
Cat. No.: HY-P2237
CAS No.: 65147-09-3
Target:  

Amino Acid Derivatives

Research Areas:  

Endocrinology

Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays .
Crovalimab
Crovalimab
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Cat. No.: HY-P99965
CAS No.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107

Target:  

Complement System

Research Areas:  

Cardiovascular Disease Metabolic Disease

Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
Cobra Venom Factor
Cobra Venom Factor
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Cat. No.: HY-NP004
Synonyms: CVF
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .
Riliprubart
Riliprubart
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Cat. No.: HY-P990091
CAS No.: 2756228-76-7
Synonyms: SAR 445088

Target:  

Complement System Fc Receptor (FcR)

Research Areas:  

Neurological Disease Inflammation/Immunology

Riliprubart (SAR 445088) is a selective anti-C1s humanized IgG4 monoclonal antibody with mutations that enhance its binding to the neonatal Fc receptor. Riliprubart blocks activation of the classical complement pathway, prevents the formation of the C3 convertase C4b2a, and inhibits complement-mediated hemolytic activity. Riliprubart can be used in research related to classical complement-mediated diseases, cold agglutinin disease, and chronic inflammatory demyelinating polyneuropathy. For the isotype control of Riliprubart, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
SPC5001 sodium
SPC5001 sodium
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Cat. No.: HY-148687A
Purity:  93.97%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sodium sequence: 5′-TGmCTACAAAACmCmCA-3′ .
Empasiprubart
Empasiprubart
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Cat. No.: HY-P990025
CAS No.: 2579031-19-7
Synonyms: ARGX-117

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models .
PCSK9 degrader 1
PCSK9 degrader 1
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Cat. No.: HY-130245
Purity:  98.33%
Target:  

PCSK9

Research Areas:  

Metabolic Disease

PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor .
GEMSA
GEMSA
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Cat. No.: HY-118120
CAS No.: 77482-44-1
Synonyms: 2-Guanidinoethylmercaptosuccinic acid
Target:  

Carboxypeptidase

Research Areas:  

Neurological Disease

GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia .
Pyr-Arg-Thr-Lys-Arg-AMC TFA
Pyr-Arg-Thr-Lys-Arg-AMC TFA
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Cat. No.: HY-P4349A
CAS No.: 1255501-99-5
Target:  

Biochemical Assay Reagents Thrombin

Research Areas:  

Others

Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide, and a fluorescent substrate. Pyr-Arg-Thr-Lys-Arg-AMC TFA can be used to detect the activity of specific proteases, such as Furin, Trypsin, and Thrombin .
Histatin-3 TFA
Histatin-3 TFA
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Cat. No.: HY-P5272
CAS No.: 112844-49-2
Target:  

Bacterial

Research Areas:  

Inflammation/Immunology

Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
Pep2-8 TFA
Pep2-8 TFA
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Cat. No.: HY-P2276A
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease Others

Pep2-8 is a peptide which has enhanced the antagonistic activity of proprotein convertase subtilin/ kexin 9 type (PCSK9) .
PF-06815345 hydrochloride
PF-06815345 hydrochloride
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Cat. No.: HY-112598A
CAS No.: 2334434-49-8
Purity:  98.15%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease Metabolic Disease

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse .
SPC5001
SPC5001
0 Images
Cat. No.: HY-148687
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .
Assay Types