112844-49-2
Chemical Structure
Histatin-3 TFA
- CAS No.: 112844-49-2
- Formula:C178H258N64O48.xC2HF3O2
- Molecular Weight:4062.35 (free acid)
SMILES: O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)CC(O)=O)=O)CC1=CC=C(O)C=C1)=O)CC(C)C)=O)CC2=CC=C(O)C=C2)=O)CC(N)=O)=O)CO)=O)CCCNC(N)=N)=O)CC3=CC=C(O)C=C3)=O)=O)CCCNC(N)=N)=O)CC4=CNC=N4)=O)CO)=O)CC5=CNC=N5)=O)CC6=CNC=N6)=O)CCCCN)=O)CCC(O)=O)=O)CC7=CNC=N7)=O)CC8=CC=CC=C8)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CC9=CC=C(O)C=C9)=O)=O)CC%10=CNC=N%10)=O)CC%11=CNC=N%11)=O)CCCNC(N)=N)=O)CCCCN)=O)C)=O)CC%12=CNC=N%12)=O)CO.O=C(C(F)(F)F)O.[x]
Biological Activity: Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Histatin-3 TFA | 98.26% | Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM. | ||||||||||||||||||||
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Keywords
