1632250-49-7
1632250-49-7
Chemical Structure
PF-06446846
- CAS No.: 1632250-49-7
- Formula:C22H20ClN7O
- Molecular Weight:433.89
IUPAC Name: (R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide
InChIKey: FDTXHWQFIXYHCL-QGZVFWFLSA-N
SMILES: O=C(C1=CC=C(C=C1)N2N=NC3=CC=CN=C32)N([C@H]4CNCCC4)C5=NC=CC=C5Cl
Biological Activity: PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region[1].
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PF-06446846 | 98.35% | PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region. | ||||||||||||||||||||
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References
Keywords
