2 Results for "

dihydroorotase

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "dihydroorotase" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-128425A
CAS No.: 13184-27-5
Purity:  ≥98.0%
Synonyms: L-Ureidosuccinic acid
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura + strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura - strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .
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1
1 Cited Publications
Cat. No.: HY-W011079
CAS No.: 1024-99-3
Research Areas:  

Infection Cancer

5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia .
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