1024-99-3
1024-99-3
Chemical Structure
5-Iodouridine
- CAS No.: 1024-99-3
- Formula:C9H11IN2O6
- Molecular Weight:370.10
IUPAC Name: 5-Iodouridine
InChIKey: RKSLVDIXBGWPIS-UAKXSSHOSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO
Biological Activity: 5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia[1][2][3].
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5-Iodouridine | 99.93% | 5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia. | ||||||||||||||||||||
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References
- [1]. Bresnick E, et al. Inhibition of dihydroorotase by purines and pyrimidines. Biochimica et Biophysica Acta (BBA)-Specialized Section on Enzymological Subjects, 1964, 81(1): 150-157.
- [2]. Kuroda Y, et al. Radiosensitization of cultured mammalian cells by 5-iodouridine. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Mar;27(3):247-57. [Content Brief]
- [3]. Kumar R, et al. Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine. J Med Chem. 1990 Feb;33(2):717-23. [Content Brief]
Keywords
