1024-99-3
1024-99-3
Chemical Structure
5-Iodouridine
- CAS No.: 1024-99-3
- Formula:C9H11IN2O6
- Molecular Weight:370.10
IUPAC Name: 5-Iodouridine
InChIKey: RKSLVDIXBGWPIS-UAKXSSHOSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO
Biological Activity: 5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Iodouridine | 99.93% | 5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia. | ||||||||||||||||||||
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5-Fluorouridine (Standard) | 99.82% | 5-Fluorouridine (Standard) is the analytical standard of 5-Fluorouridine. This product is intended for research and analytical applications. 5-Fluorouridine, a metabolite of5-Fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis. | ||||||||||||||||||||
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5-Aminouridine | 99.31% | 5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses. | ||||||||||||||||||||
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5-Chlorouridine | 5-Chlorouridine, a ribonucleoside, is an inhibitor of RNase A (Ki = 44.5 μM) and eosinophil derived neurotoxin (EDN) (Ki = 1080.1 μM; IC50 = 1462.8 μM). 5-Chlorouridine can be used for the researches of inflammatory disorders and hypereosinophilic syndromes. | |||||||||||||||||||||
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5-Hydroxy-2’-O-methyluridine | 5-Hydroxy-2’-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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5-Iodo-3’-deoxy-3’-fluorouridine | 5-Iodo-3’-deoxy-3’-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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1-(b-D-Xylofuranosyl)-5-fluorouracil | 1-(b-D-Xylofuranosyl)-5-fluorouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione | 1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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5-Bromouridine | 99.89% | 5-Bromouridine is a brominated uridine nucleoside. The triphosphate form of 5-Bromouridine, 5BrdUTP, can substitute for TTP as a substrate for DNA polymerase and be incorporated into nascent DNA strands, rendering the resulting 5-bromouridine-labeled DNA photosensitive to 300 nm UV irradiation; upon UV irradiation, the 5BrdU signal decreases and dU is generated, accompanied by DNA strand breaks and cross-link formation. 5-Bromouridine is useful for studies on nucleoside structure and halogenated nucleoside-labeled nucleic acids. | ||||||||||||||||||||
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2'-O-Methyl-5-iodouridine | 99.63% | 2’-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||||||||||||||||||||
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1-Beta-D-arabinofuranosyl-5-iodouracil | 1-Beta-D-arabinofuranosyl-5-iodouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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References
- [1]. Bresnick E, et al. Inhibition of dihydroorotase by purines and pyrimidines. Biochimica et Biophysica Acta (BBA)-Specialized Section on Enzymological Subjects, 1964, 81(1): 150-157.
- [2]. Kuroda Y, et al. Radiosensitization of cultured mammalian cells by 5-iodouridine. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Mar;27(3):247-57. [Content Brief]
- [3]. Kumar R, et al. Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine. J Med Chem. 1990 Feb;33(2):717-23. [Content Brief]
