1-(b-D-Xylofuranosyl)-5-fluorouracil
(Synonyms: 5-Fluoro-xylo-uridine; (R)-5-Fluorouridine)
1-(b-D-Xylofuranosyl)-5-fluorouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 3803-28-9
- Formula: C9H11FN2O6
- Molecular Weight:262.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Biological Activity
Description
1-(b-D-Xylofuranosyl)-5-fluorouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.9 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of A-549 tumor cell line from lung.
Compound was tested for its inhibitory effect on the growth of A-549 tumor cell line from lung.
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10.1016/0960-894X(96)00339-3 |
| AZ-521 cell line | IC50 |
0.05 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of AZ-521 tumor cell line from stomach.
Compound was tested for its inhibitory effect on the growth of AZ-521 tumor cell line from stomach.
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10.1016/0960-894X(96)00339-3 |
| COLO 320DM | IC50 |
0.0054 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of COLO 320DM tumor cell line from colon.
Compound was tested for its inhibitory effect on the growth of COLO 320DM tumor cell line from colon.
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10.1016/0960-894X(96)00339-3 |
| DLD-1 | IC50 |
0.073 μM
Compound: FUrd (5-fluorouridine)
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Compound was tested for its inhibitory effect on the growth of DLD-1 tumor cell line from colon.
Compound was tested for its inhibitory effect on the growth of DLD-1 tumor cell line from colon.
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10.1016/0960-894X(96)00339-3 |
| FM3A | IC50 |
0.014 μM
Compound: 5-FUrd
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Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis
Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis
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[PMID: 21330014] |
| HCT-15 | IC50 |
0.047 μM
Compound: FUrd (5-fluorouridine)
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Compound was tested for its inhibitory effect on the growth of HCT-15 tumor cell line from colon.
Compound was tested for its inhibitory effect on the growth of HCT-15 tumor cell line from colon.
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10.1016/0960-894X(96)00339-3 |
| HeLa | IC50 |
0.016 μM
Compound: 5-FUrd
|
Cytostatic activity against human HeLa cells in presence of 500 uM uracil
Cytostatic activity against human HeLa cells in presence of 500 uM uracil
|
[PMID: 21330014] |
| HeLa | IC50 |
0.017 μM
Compound: 5-FUrd
|
Cytostatic activity against human HeLa cells in presence of 20 uM thymidine
Cytostatic activity against human HeLa cells in presence of 20 uM thymidine
|
[PMID: 21330014] |
| HeLa | IC50 |
0.022 μM
Compound: 5-FUrd
|
Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine
Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine
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[PMID: 21330014] |
| HeLa | IC50 |
1.6 μM
Compound: 5-FUrd
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Cytostatic activity against human HeLa cells in presence of 500 uM uridine
Cytostatic activity against human HeLa cells in presence of 500 uM uridine
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[PMID: 21330014] |
| HT-1080 | IC50 |
0.041 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of HT1080 sarcoma tumor cell line.
Compound was tested for its inhibitory effect on the growth of HT1080 sarcoma tumor cell line.
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10.1016/0960-894X(96)00339-3 |
| IM-9 | IC50 |
<0.01 μg/mL
Compound: 5-F-Urd
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In vitro antitumor activity in IM-9 cell lines
In vitro antitumor activity in IM-9 cell lines
|
[PMID: 8648611] |
| K562 | IC50 |
0.026 μg/mL
Compound: 5-F-Urd
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In vitro antitumor activity in K-562 cell lines
In vitro antitumor activity in K-562 cell lines
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[PMID: 8648611] |
| KKLS | IC50 |
0.016 μM
Compound: FUrd (5-fluorouridine)
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Compound was tested for its inhibitory effect on the growth of KKLS tumor cell line from stomach.
Compound was tested for its inhibitory effect on the growth of KKLS tumor cell line from stomach.
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10.1016/0960-894X(96)00339-3 |
| L1210 | IC50 |
0.0075 μM
Compound: 5-FUrd
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Cytostatic activity against mouse L1210 cells in presence of 500 uM uracil
Cytostatic activity against mouse L1210 cells in presence of 500 uM uracil
|
[PMID: 21330014] |
| L1210 | IC50 |
0.014 μM
Compound: 5-FUrd
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Cytostatic activity against mouse L1210 cells after 2 days by coulter counting analysis
Cytostatic activity against mouse L1210 cells after 2 days by coulter counting analysis
|
[PMID: 21330014] |
| L1210 | IC50 |
0.026 μM
Compound: 5-FUrd
|
Cytostatic activity against mouse L1210 cells in presence of 20 uM 2'-deoxyuridine
Cytostatic activity against mouse L1210 cells in presence of 20 uM 2'-deoxyuridine
|
[PMID: 21330014] |
| L1210 | IC50 |
0.72 μM
Compound: 5-FUrd
|
Cytostatic activity against mouse L1210 cells in presence of 500 uM uridine
Cytostatic activity against mouse L1210 cells in presence of 500 uM uridine
|
[PMID: 21330014] |
| L1210 | IC50 |
1.2 μM
Compound: 5-FUrd
|
Cytostatic activity against mouse L1210 cells in presence of 20 uM thymidine
Cytostatic activity against mouse L1210 cells in presence of 20 uM thymidine
|
[PMID: 21330014] |
| MKN-28 | IC50 |
0.028 μM
Compound: FUrd (5-fluorouridine)
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Compound was tested for its inhibitory effect on the growth of MKN-28 tumor cell line from stomach.
Compound was tested for its inhibitory effect on the growth of MKN-28 tumor cell line from stomach.
|
10.1016/0960-894X(96)00339-3 |
| MKN-45 | IC50 |
0.026 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of MKN-45 tumor cell line from stomach.
Compound was tested for its inhibitory effect on the growth of MKN-45 tumor cell line from stomach.
|
10.1016/0960-894X(96)00339-3 |
| MOLT-3 | IC50 |
<0.01 μg/mL
Compound: 5-F-Urd
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In vitro antitumor activity in MOLT-3 cell lines
In vitro antitumor activity in MOLT-3 cell lines
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[PMID: 8648611] |
| NUGC-3 | IC50 |
0.022 μM
Compound: FUrd (5-fluorouridine)
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Compound was tested for its inhibitory effect on the growth of NUGC-3 tumor cell line from stomach.
Compound was tested for its inhibitory effect on the growth of NUGC-3 tumor cell line from stomach.
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10.1016/0960-894X(96)00339-3 |
| PANC-1 | IC50 |
11 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of PANC-1 tumor cell line from pancreas.
Compound was tested for its inhibitory effect on the growth of PANC-1 tumor cell line from pancreas.
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10.1016/0960-894X(96)00339-3 |
| PHA-Ly | IC50 |
<0.1 μg/mL
Compound: 5-F-Urd
|
IIn vitro antitumor activity in PHA-Ly cell lines
IIn vitro antitumor activity in PHA-Ly cell lines
|
[PMID: 8648611] |
| SNU-C2A | IC50 |
0.045 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of SUN-C2A tumor cell line from colon.
Compound was tested for its inhibitory effect on the growth of SUN-C2A tumor cell line from colon.
|
10.1016/0960-894X(96)00339-3 |
| SW48 | IC50 |
0.016 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of SW-48 tumor cell line from colon.
Compound was tested for its inhibitory effect on the growth of SW-48 tumor cell line from colon.
|
10.1016/0960-894X(96)00339-3 |
| T-24 | IC50 |
0.014 μM
Compound: FUrd (5-fluorouridine)
|
Compound was tested for its inhibitory effect on the growth of T24 tumor cell line from bladder.
Compound was tested for its inhibitory effect on the growth of T24 tumor cell line from bladder.
|
10.1016/0960-894X(96)00339-3 |
| U-937 | IC50 |
<0.01 μg/mL
Compound: 5-F-Urd
|
In vitro antitumor activity in U-937 cell lines
In vitro antitumor activity in U-937 cell lines
|
[PMID: 8648611] |
Chemical Information
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CAS No. 3803-28-9
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Molecular Weight 262.19
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Formula C9H11FN2O6
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SMILES
OC[C@H]1O[C@@H](N(C(N2)=O)C=C(F)C2=O)[C@H](O)[C@H]1O
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Synonyms
5-Fluoro-xylo-uridine; (R)-5-Fluorouridine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
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1-(b-D-Xylofuranosyl)-5-fluorouracil Related Classifications
HY-154128 Related Classifications
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