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By Targets:	Akt (2) Apoptosis (4) Autophagy (2) Bacterial (5) Biochemical Assay Reagents (1) Calcium Channel (1) Drug Derivative (1) Endogenous Metabolite (6) Environmental Pollutants (1) ERK (1) Fatty Acid Synthase (FASN) (2) Interleukin Related (1) JNK (1) mRNA (1) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Toll-like Receptor (TLR) (1) Transthyretin (TTR) (1) VD/VDR (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (4)
Oligonucleotides:	mRNA (1) Interleukin & Receptors (1)

Inhibitors & Agonists

Peptides

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Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15398

Vitamin D3 20+ Cited Publications Cholecalciferol; Colecalciferol	Environmental Pollutants Endogenous Metabolite Bacterial VD/VDR	Metabolic Disease Cancer
Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-N2486

Desoxyrhaponticin 1 Publications Verification	Fatty Acid Synthase (FASN) Apoptosis	Cancer
Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects.

HY-19934

Pifusertib TAS-117	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy .

HY-19934A

Pifusertib hydrochloride TAS-117 hydrochloride	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy .

HY-15398R

Vitamin D3 (Standard) Cholecalciferol (Standard); Colecalciferol (Standard)	Reference Standards VD/VDR Endogenous Metabolite Bacterial	Metabolic Disease Cancer
Vitamin D3 (Standard) is the analytical standard of Vitamin D3. This product is intended for research and analytical applications. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-W001117

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

HY-N2486R

Desoxyrhaponticin (Standard)	Reference Standards Fatty Acid Synthase (FASN) Apoptosis	Cancer
Desoxyrhaponticin (Standard) is the analytical standard of Desoxyrhaponticin. This product is intended for research and analytical applications. Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .

HY-174631

Human IL18 mRNA	mRNA	Inflammation/Immunology
Human IL18 mRNA encodes the human interleukin 18 (IL18) protein, a proinflammatory cytokine of the IL-1 family. IL18 is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-176233

Transthyretin-IN-4	Transthyretin (TTR)	Cardiovascular Disease
Transthyretin-IN-4 (Compound B26) is a bivalent inhibitor of transthyretin (TTR) amyloidosis (bIC₅₀: 0.09 µM, pIC₅₀: 1.4 µM). Transthyretin-IN-4 is used in the study of fatal heart failure with preserved ejection fraction (HFpEF) and fatal arrhythmias .

HY-W001117R

3,5-Dimethoxyphenol (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

HY-121390

Lasiocarpine	Endogenous Metabolite	Cancer
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-156121

NLRP3-IN-20	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC₅₀ of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis .

HY-W317408

(+)-Menthyl acetate	Biochemical Assay Reagents	Others
(+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC₅₀=34.0 μg?mL ^-1, and lower than that of SK-Mel-28 cell line, IC₅₀=279.9 μg?mL ^-1, on A549 cell without fatal .

HY-181434

Spiroxasone	Drug Derivative	Endocrinology
Spiroxasone is an orallyactive thioacetyl-containing steroid. Spiroxasone can prevent fatal renal damage and nephrocalcinosis associated with acute mercuric chloride intoxication. Spiroxasone can be used for the research of acute HgCl₂ poisoning .

HY-118971

CHIR-29498	Bacterial	Infection
CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus .

HY-121390A

Lasiocarpine hydrochloride	Endogenous Metabolite	Cancer
Lasiocarpine hydrochloride, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine hydrochloride is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-106458

Niludipine Bay a 7168	Calcium Channel	Cardiovascular Disease
Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia .

Cat. No.	Product Name	Target	Research Area

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

Vitamin D3 20+ Cited Publications Cholecalciferol; Colecalciferol	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Bacterial VD/VDR
Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

Desoxyrhaponticin 1 Publications Verification	Monophenols Stilbenes Classification of Application Fields Polygonaceae Rheum rhabarbarum Linnaeus Phenols Plants Rheum tanguticum Disease Research Fields Source Classification Cancer	Fatty Acid Synthase (FASN) Apoptosis
Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects.

Vitamin D3 (Standard) Cholecalciferol (Standard); Colecalciferol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards VD/VDR Endogenous Metabolite Bacterial
Vitamin D3 (Standard) is the analytical standard of Vitamin D3. This product is intended for research and analytical applications. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Schisandra sphenanthera Rehd. et Wils Monophenols Classification of Application Fields Taxaceae Phenols Metabolic Disease Plants Schisandraceae Disease Research Fields Source Classification Taxus chinensis (Pilger) Rehd.	Endogenous Metabolite
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

Desoxyrhaponticin (Standard)	Structural Classification Monophenols Stilbenes Polygonaceae Rheum rhabarbarum Linnaeus Phenols Plants Rheum tanguticum Source Classification	Reference Standards Fatty Acid Synthase (FASN) Apoptosis
Desoxyrhaponticin (Standard) is the analytical standard of Desoxyrhaponticin. This product is intended for research and analytical applications. Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .

3,5-Dimethoxyphenol (Standard)	Schisandra sphenanthera Rehd. et Wils Structural Classification Monophenols Taxaceae Phenols Plants Schisandraceae Taxus chinensis (Pilger) Rehd. Source Classification	Reference Standards Endogenous Metabolite
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer Source Classification	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

Cat. No.	Product Name		Classification

HY-174631

Human IL18 mRNA		mRNA Interleukin & Receptors
Human IL18 mRNA encodes the human interleukin 18 (IL18) protein, a proinflammatory cytokine of the IL-1 family. IL18 is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.

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Inhibitors & Agonists

Peptides

NaturalProducts

Oligonucleotides

Natural
Products