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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
fatal
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "fatal" in MCE Product Catalog:
27
27 Cited Publications
Synonyms: Cholecalciferol; Colecalciferol
1
1 Cited Publications
Cat. No.: HY-N2486
CAS No.: 30197-14-9
Category:
Monophenols Stilbenes Polygonaceae Rheum rhabarbarum Linnaeus Phenols Plants Disease Research Fields Rheum tanguticum Cancer
Target:
Cat. No.: HY-19934
CAS No.: 1402602-94-1
Synonyms: TAS-117
Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy .
Cat. No.: HY-19934A
CAS No.: 2930090-28-9
Synonyms: TAS-117 hydrochloride
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy .
Synonyms: Cholecalciferol (Standard); Colecalciferol (Standard)
Cat. No.: HY-W001117
CAS No.: 500-99-2
Synonyms: Phloroglucinol Dimethyl Ether
Category:
Schisandra sphenanthera Rehd. et Wils Monophenols Taxaceae Metabolic Disease Phenols Plants Schisandraceae Disease Research Fields Taxus chinensis (Pilger) Rehd.
Target:
Cat. No.: HY-N2486R
CAS No.: 30197-14-9
Cat. No.: HY-174631
Target:
Research Areas:
Human IL18 mRNA encodes the human interleukin 18 (IL18) protein, a proinflammatory cytokine of the IL-1 family. IL18 is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.
Cat. No.: HY-P5724
Cat. No.: HY-P11250
Target:
Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK
Research Areas:
Cat. No.: HY-176233
CAS No.: 2765296-93-1
Target:
Research Areas:
Transthyretin-IN-4 (Compound B26) is a bivalent inhibitor of transthyretin (TTR) amyloidosis (bIC50: 0.09 µM, pIC50: 1.4 µM). Transthyretin-IN-4 is used in the study of fatal heart failure with preserved ejection fraction (HFpEF) and fatal arrhythmias .
Cat. No.: HY-W001117R
CAS No.: 500-99-2
Category:
Alkaloids Pyrrole Alkaloids Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer
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Cat. No.: HY-156121
CAS No.: 2428478-22-0
Target:
Research Areas:
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis .
Cat. No.: HY-W317408
CAS No.: 5157-89-1
Target:
Research Areas:
(+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC50=34.0 μg?mL -1, and lower than that of SK-Mel-28 cell line, IC50=279.9 μg?mL -1, on A549 cell without fatal .
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Spiroxasone is an orallyactive thioacetyl-containing steroid. Spiroxasone can prevent fatal renal damage and nephrocalcinosis associated with acute mercuric chloride intoxication. Spiroxasone can be used for the research of acute HgCl2 poisoning .
Cat. No.: HY-118971
CAS No.: 236102-25-3
CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus .
Cat. No.: HY-121390A
CAS No.: 1976-49-4
Target:
Research Areas:
Lasiocarpine hydrochloride, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine hydrochloride is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .
Cat. No.: HY-106458
CAS No.: 22609-73-0
Synonyms: Bay a 7168
Target:
Research Areas:
Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
