1402602-94-1
Chemical Structure
Pifusertib
Synonym(s): TAS-117
- CAS No.: 1402602-94-1
- Formula:C26H24N4O2
- Molecular Weight:424.49
IUPAC Name: (1r,3r)-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl)cyclobutan-1-ol
InChIKey: AIFGVDXMHWGOGJ-DIVCQZSQSA-N
SMILES: C[C@@](C1)(O)C[C@]1(N)C2=CC=C(C3=C(N(COC4=CC=NC=C45)C5=N3)C6=CC=CC=C6)C=C2
Biological Activity: Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pifusertib | 99.81% | Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy. | ||||||||||||||||||||
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Similarity Score 0.99
HY-19934APifusertib hydrochloride -
Similarity Score 0.55
HY-138767AKT-IN-5 -
Similarity Score 0.55
HY-100018BAY1125976 -
Similarity Score 0.53
HY-10357MK-2206 free base -
Similarity Score 0.52
HY-151504Engasertib -
Similarity Score 0.52
HY-108232MK-2206 -
Similarity Score 0.52
HY-10358MK-2206 dihydrochloride -
Similarity Score 0.50
HY-19719Miransertib -
Similarity Score 0.50
HY-18296AKT-IN-1 -
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