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  4. Spiroxasone

Spiroxasone is an orallyactive thioacetyl-containing steroid. Spiroxasone can prevent fatal renal damage and nephrocalcinosis associated with acute mercuric chloride intoxication. Spiroxasone can be used for the research of acute HgCl2 poisoning.

For research use only. We do not sell to patients.

Spiroxasone

Spiroxasone Chemical Structure

CAS No. : 6673-97-8

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Spiroxasone Related Antibodies

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Description

Spiroxasone is an orallyactive thioacetyl-containing steroid. Spiroxasone can prevent fatal renal damage and nephrocalcinosis associated with acute mercuric chloride intoxication. Spiroxasone can be used for the research of acute HgCl2 poisoning[1].

In Vivo

Spiroxasone (10 mg; p.o.; 1 hour before HgCl2 administration) offers excellent protection against both nephrocalcinosis and mortality induced by acute HgCl2 poisoning (300 μg i.v.) in female ARS/Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ARS/Sprague-Dawley with acute mercuric chloride poisoning (female, 90-110 g)[1]
Dosage: 10 mg
Administration: p.o.; 1 hour before HgCl₂ administration
Result: Achieved a nephrocalcinosis score of 0 (no lesion) and yielded 0% mortality.
Molecular Weight

402.59

Formula

C24H34O3S
CAS No.
SMILES

CC(S[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]4(CCCO4)CC3)(CC[C@]2([H])[C@@]5(C(C1)=CC(CC5)=O)C)C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Spiroxasone Related Classifications

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Keywords:

Spiroxasone6673-97-8Drug DerivativeDrug derivativenephrocalcinosisHgCl2poisoningrenal damageARS/Sprague-Dawley ratsInhibitorinhibitorinhibit

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