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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
human ACC1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "human ACC1" in MCE Product Catalog:
24
24 Cited Publications
Cat. No.: HY-16901
CAS No.: 1434635-54-7
Synonyms: ND-630; GS-0976; NDI-010976
Target:
Research Areas:
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
3
3 Cited Publications
Target:
Research Areas:
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
Cat. No.: HY-160912
CAS No.: 1135000-36-0
Target:
Research Areas:
ELOVL6-IN-5 is an orally active and selective elongase enzyme of long-chain fatty acid family 6 (ELOVL6) inhibitor with IC50 values of 85 nM and 38 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-5 shows >60-fold selectivity over other ELOVL family enzymes (ELOVL1, 2, 3, 5) and no effect on other lipid synthesis enzymes like ACC1, ACC2. ELOVL6-IN-5 reduces hepatic fatty acid composition ratio of C18 to C16 in diet-induced obesity (DIO) and KKAy mice. ELOVL6 inhibition by ELOVL6-IN-5 does not improve insulin resistance. ELOVL6-IN-5 can be used for the research of metabolic disease .
Target:
Research Areas:
CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .
Cat. No.: HY-179537
CAS No.: 1786406-66-3
Synonyms: CKBA
Research Areas:
Selovoxolone (CKBA), a derivative of AKBA (HY-N0892) is an inhibitor of acetyl-CoA carboxylase 1 (ACC1), with an IC50 of 5.02 μM. Selovoxolone inhibits the differentiation of Th17 cells and has IC50 values of 3.28 μM for mouse cells and 3.61 μM for human cells. Selovoxolone ointment significantly alleviates psoriasis-like inflammation in mice. Selovoxolone can be used for the study of psoriasis .
Cat. No.: HY-16901R
CAS No.: 1434635-54-7
Synonyms: ND-630 (Standard); GS-0976 (Standard); NDI-010976 (Standard)
Research Areas:
Firsocostat (Standard) is the analytical standard of Firsocostat. This product is intended for research and analytical applications. Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
Cat. No.: HY-P75590
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BCL2A1; ACC-1; Prev. HBPA1; ACC2; BCL2L5; ACC1; BFL1; Bcl-2-Like Protein 5; GRS; Bcl2-L-5; Hemopoietic-Specific Early Response Protein; Hematopoietic BCL2-Related Protein A1; Bcl-2-Related Protein A1; Protein GRS; Protein BFL-1; BCL2 Related Protein A1; A
Species:
Human
Source:
E. coli
Cat. No.: HY-183919
CAS No.: 2237229-78-4
Research Areas:
ACC2-IN-1 is an orally active, selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 of 1.9 nM against human targets. ACC2-IN-1 acts as a reducing agent to decrease malonyl-CoA levels in skeletal muscle and exhibits a favorable CYP450 inhibition profile. ACC2-IN-1 can be used in the research of type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
