89 Results for "

human IgG4κ

" in MedChemExpress (MCE) Product Catalog:
Products (89)

89 Results for "human IgG4κ" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-P99003

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.
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5
5 Cited Publications
Cat. No.: HY-P990545
CAS No.: 2065212-40-8
Synonyms: ANX005

Target:  

Complement System

Research Areas:  

Neurological Disease

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG4 kappa, Isotype Control (HY-P99003). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .
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1
1 Cited Publications
Cat. No.: HY-P99264
CAS No.: 1660159-36-3
Synonyms: humanized Anti-CD22 Recombinant Antibody

Research Areas:  

Cancer

Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent Ozogamicin as an antibody-drug conjugate (ADC), Inotuzumab ozogamicin (HY-P9959). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .
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1
1 Cited Publications
Cat. No.: HY-P991117
CAS No.: 3008610-20-3
Synonyms: REGN-9933

Target:  

Factor Xa

Research Areas:  

Cardiovascular Disease

Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P99971
CAS No.: 2924764-21-4

Research Areas:  

Cancer

Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P99299
CAS No.: 845816-02-6
Synonyms: HGS-ETR 2; ETR2-ST01

Target:  

Apoptosis

Research Areas:  

Cancer

Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
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Cat. No.: HY-P99453
CAS No.: 1826819-57-1

Target:  

ADC Antibodies

Research Areas:  

Cancer

Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .
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Cat. No.: HY-P99499
CAS No.: 2050478-92-5
Synonyms: JNJ 63723283; JNJ 3283

Research Areas:  

Cancer

Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .
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Cat. No.: HY-P991219
Synonyms: EnX209

Research Areas:  

Inflammation/Immunology

Anti-IL11RA Antibody (X209) (EnX209) is a human-derived IgG4, κ-type antibody inhibitor targeting IL11RA, with a KD of 6 nM. Anti-IL11RA Antibody (X209) blocks the IL11RA signaling pathway, inhibits ERK-dependent activation, and reduces the activation level of ERK1/2. Anti-IL11RA Antibody (X209) exerts a protective effect against fibrosis. Anti-IL11RA Antibody (X209) is applicable to studies related to liver fibrosis, cardiac fibrosis and other related conditions. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P990073
CAS No.: 2648058-48-2
Synonyms: REGN-5093

Target:  

c-Met/HGFR

Research Areas:  

Cancer

Davutamig (REGN-5093) is a human IgG4-kappa, anti-MET bispecific antibody. Davutamig binds 2 distinct epitopes of MET, blocking ligand binding and inducing MET internalization and degradation. Davutamig is applicable to the research of advanced non-small cell lung cancer with MET gene abnormalities .
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Cat. No.: HY-P990481

Target:  

PACAP Receptor

Research Areas:  

Inflammation/Immunology

Anti-PACAP38 Antibody is a human antibody expressed in CHO cells, targeting PACAP38. The Anti-PACAP38 Antibody has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-PACAP38 Antibody can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991201

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

REGN-7257 is a humanized monoclonal antibody targeting IL2RG. REGN-7257 blocks the signal transduction induced by common gamma chain (γc) cytokines via the IL2RG chain of the γc cytokine receptor complex. REGN-7257 is applicable for research on immune-mediated diseases and T cell-mediated diseases . Its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P990669
CAS No.: 2241728-76-5

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Torudokimab is a humanized antibody expressed in CHO, targeting IL-33. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P99264A
CAS No.: 1660159-36-3
Synonyms: humanized Anti-CD22 Recombinant Antibody (powder)

Research Areas:  

Cancer

Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) (powder) is a humanized IgG4κ antibody that targets human CD22. Inotuzumab (powder) can be linked to a toxic agent Ozogamicin as an antibody-drug conjugate (ADC), Inotuzumab ozogamicin (HY-P9959). Inotuzumab (powder) can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .
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Cat. No.: HY-P990770
CAS No.: 2414559-57-0

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Ucenprubart is an anti-CD200R1 human IgG4κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991698
CAS No.: 2785392-78-9
Synonyms: BAT-1308

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Liscastobart is a humanized IgG4κ antibody targeting PDCD1/PD-1/CD279. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P991705
CAS No.: 2911556-99-3
Synonyms: JJP-1212

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Nebaprubart (JJP-1212) is a humanized IgG4κ antibody against FCAR/CD89, and its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003). Nebaprubart works by blocking a key receptor involved in inflammation .
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Cat. No.: HY-P991038
CAS No.: 2904575-77-3

Target:  

CD28

Research Areas:  

Inflammation/Immunology

HY-P991038 is an BTLA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P990913
CAS No.: 2765077-69-6
Synonyms: bsAb7075; REGN-7075; Marlotamig

Target:  

EGFR

Research Areas:  

Inflammation/Immunology

HY-P990913 is an EGFR/CD28-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P990737
CAS No.: 2484883-56-7
Synonyms: LY-3041658

Target:  

CXCR

Research Areas:  

Inflammation/Immunology

Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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