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human arginase 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arginase (3) Reference Standards (1)
By Research Areas:	Cancer (3)

Inhibitors & Agonists

Recombinant Proteins

Targets Recommended: Arginase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101979

Numidargistat 10+ Cited Publications CB-1158; INCB01158	Arginase	Cancer
Numidargistat (CB-1158) is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human* arginase 1** and recombinant human arginase 2, respectively. Immuno-oncology agent .

HY-101979A

Numidargistat dihydrochloride 10+ Cited Publications CB-1158 dihydrochloride; INCB01158 dihydrochloride	Arginase	Cancer
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human* arginase 1** and recombinant human arginase 2, respectively. Immuno-oncology agent .

HY-101979R

Numidargistat (Standard) CB-1158 (Standard); INCB01158 (Standard)	Reference Standards Arginase	Cancer
Numidargistat (Standard) is the analytical standard of Numidargistat (HY-101979). This product is intended for research and analytical applications. Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7603

	Arginase-2/ARG2 Protein, Human (His) rHuarginase-2, His; ARG2; arginase-2	Human	E. coli
	Arginase-2/ARG2 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Arginase-2 (Arg2) acts as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose intolerance in obese murine models.

HY-P705455

	Arginase-2/ARG2 Protein, Human (332a.a, His) arginase-2, mitochondrial; ARG2; arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase	Human	E. coli

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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