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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
immunotoxic
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "immunotoxic" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82
6
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Art. -Nr.: HY-W105970
CAS. Nr.: 7758-16-9
Synonyms: Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
1
1
1 Cited Publications
Synonyms: Bis(2-ethylhexyl) phthalate (Standard); Ergoplast FDO (Standard); ESBO-D 82 (Standard)
Category:
Synonyms: Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA
Target:
Forschungsgebiete:
Neurological Disease Metabolic Disease Inflammation/Immunology
Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .
Art. -Nr.: HY-W041608
CAS. Nr.: 26172-55-4
Target:
Forschungsgebiete:
Methylchloroisothiazolinone is a widely used fungicide and also an aquatic pollutant with pro-inflammatory activity and neurotoxicity. Methylchloroisothiazolinone induces the production of pro-inflammatory cytokines (such as IL-1β, TNF-α, IL-6) by activating the NF-κB signaling pathway and upregulating TLR4 expression, thereby triggering allergic contact dermatitis. Methylchloroisothiazolinone reduces cholinesterase activity and exacerbates oxidative stress by impairing catalase activity and disrupting redox balance. Methylchloroisothiazolinone poses significant harm to Mediterranean mussels, reducing the viability of hemocytes and digestive gland cells, inhibiting immune phagocytic function, and disrupting osmoregulatory capacity. Methylchloroisothiazolinone is used in studies on allergic contact dermatitis and related immunotoxicity mechanisms .
Forschungsgebiete:
Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .
Art. -Nr.: HY-B2010
CAS. Nr.: 72178-02-0
Target:
Environmental Pollutants Reactive Oxygen Species (ROS) Herbicide Protoporphyrinogen IX oxidase Apoptosis
Forschungsgebiete:
Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards .
Art. -Nr.: HY-W014225R
CAS. Nr.: 3739-38-6
Synonyms: 3-PBA (Standard)
Art. -Nr.: HY-B2035
CAS. Nr.: 51218-49-6
Target:
Herbicide Environmental Pollutants Caspase Cytochrome P450 MDM-2/p53 Interleukin Related Reactive Oxygen Species (ROS) Apoptosis
Forschungsgebiete:
Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .
Art. -Nr.: HY-W014225S
CAS. Nr.: 1793055-05-6
Synonyms: 3-PBA-13C6
Art. -Nr.: HY-108385
CAS. Nr.: 1448049-50-0
Target:
Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis PPAR Reactive Oxygen Species (ROS) Apoptosis Fungal
Forschungsgebiete:
Ochratoxin A-D4 (Phe-OTA-D4) is the deuterium labeled Ochratoxin A. Ochratoxin A is an orally active food-borne mycotoxin that can cross the blood-brain barrier. Ochratoxin A is a secondary metabolite of fungi belonging to the genera Aspergillus and Penicillium, and is classified as a Group 2B carcinogen. Ochratoxin A exerts its effects through multiple pathways, including inducing oxidative stress, inhibiting mitochondrial respiration, causing oxidative DNA damage, disrupting the PPAR-γ-CD36 axis, inducing immunosuppression, generating ROS, mediating mitochondria-dependent apoptosis, inhibiting glutamate uptake, triggering demyelination and neuroinflammation, inducing DNA hypomethylation, and inhibiting cell proliferation. Ochratoxin A can induce nephrotoxicity, hepatotoxicity, immunotoxicity, and neurotoxicity, and also exhibits mutagenicity, teratogenicity, and carcinogenicity.
Target:
Forschungsgebiete:
Dibromoacetic acid (Standard) is the analytical standard of Dibromoacetic acid. This product is intended for research and analytical applications. Dibromoacetic acid, a haloacetic acid found in drinking water as a disinfection by-product, can cause many adverse effects, including immunotoxicity and apoptosis .
Art. -Nr.: HY-136355S
Art. -Nr.: HY-136355R
CAS. Nr.: 117428-22-5
Forschungsgebiete:
Picoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .
Art. -Nr.: HY-B2010S
Art. -Nr.: HY-B2010R
CAS. Nr.: 72178-02-0
Target:
Herbicide Reference Standards Protoporphyrinogen IX oxidase Apoptosis Reactive Oxygen Species (ROS)
Forschungsgebiete:
Fomesafen (Standard) is the analytical standard of Fomesafen (HY-B2010). This product is intended for research and analytical applications. Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards .
Art. -Nr.: HY-N0260R
CAS. Nr.: 110642-44-9
Synonyms: Epimedin-C (Standard); Baohuoside-VI (Standard)
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
