26172-55-4
Chemical Structure
Methylchloroisothiazolinone
- CAS No.: 26172-55-4
- Formula:C4H4ClNOS
- Molecular Weight:149.60
IUPAC Name: 5-chloro-2-methylisothiazol-3(2H)-one
InChIKey: DHNRXBZYEKSXIM-UHFFFAOYSA-N
SMILES: O=C1N(C)SC(Cl)=C1
Biological Activity: Methylchloroisothiazolinone is a widely used fungicide and also an aquatic pollutant with pro-inflammatory activity and neurotoxicity. Methylchloroisothiazolinone induces the production of pro-inflammatory cytokines (such as IL-1β, TNF-α, IL-6) by activating the NF-κB signaling pathway and upregulating TLR4 expression, thereby triggering allergic contact dermatitis. Methylchloroisothiazolinone reduces cholinesterase activity and exacerbates oxidative stress by impairing catalase activity and disrupting redox balance. Methylchloroisothiazolinone poses significant harm to Mediterranean mussels, reducing the viability of hemocytes and digestive gland cells, inhibiting immune phagocytic function, and disrupting osmoregulatory capacity. Methylchloroisothiazolinone is used in studies on allergic contact dermatitis and related immunotoxicity mechanisms[1][2].
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Methylchloroisothiazolinone | Methylchloroisothiazolinone is a widely used fungicide and also an aquatic pollutant with pro-inflammatory activity and neurotoxicity. Methylchloroisothiazolinone induces the production of pro-inflammatory cytokines (such as IL-1β, TNF-α, IL-6) by activating the NF-κB signaling pathway and upregulating TLR4 expression, thereby triggering allergic contact dermatitis. Methylchloroisothiazolinone reduces cholinesterase activity and exacerbates oxidative stress by impairing catalase activity and disrupting redox balance. Methylchloroisothiazolinone poses significant harm to Mediterranean mussels, reducing the viability of hemocytes and digestive gland cells, inhibiting immune phagocytic function, and disrupting osmoregulatory capacity. Methylchloroisothiazolinone is used in studies on allergic contact dermatitis and related immunotoxicity mechanisms. | |||||||||||||||||||||
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5-Chloro-2-methylisothiazol-3(2H)-one-d3 | 5-Chloro-2-methylisothiazol-3(2H)-one-d3 is a deuterium labeled compound. | |||||||||||||||||||||
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- [1]. Goes H F O, et al. Proinflammatory and regulatory mechanisms in allergic contact dermatitis caused by methylchloroisothiazolinone and methylisothiazolinone[J]. Experimental dermatology, 2020, 29(5): 490-498.
- [2]. Multisanti C R, et al. From biocide to biohazard: influence of methylchloroisothiazolinone on physiological integrity of Mytilus galloprovincialis[J]. Emerging Contaminants, 2025: 100617.
