208 Results for "

lectins

" in MedChemExpress (MCE) Product Catalog:
Products (208)

208 Results for "lectins" in MCE Product Catalog:

92
FITC
FITC
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92 Publications Verification
Cat. No.: HY-66019
CAS No.: 3326-32-7
Synonyms: Fluorescein 5-isothiocyanate
FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity and excellent fluorescence quantum yield. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm. In addition, FITC is also a hapten that can induce contact hypersensitivity (CHS) and induce an atopic dermatitis model .
12
Streptavidin Agarose 6FF
Streptavidin Agarose 6FF
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12 Cited Publications
Cat. No.: HY-K0218A

MCE Streptavidin Agarose 6FF, a 6% highly cross-linked agarose reagent coupled with recombinant streptavidin, is an affinity chromatography medium for separation and purification of biotinylated peptides, antibodies, lectins, etc. The total binding capacity of Streptavidin Agarose 6FF is more than 200 nmol of D-Biotin/mL settled resin.

7
Phytohemagglutinin
Phytohemagglutinin
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7 Cited Publications
Cat. No.: HY-N7038
CAS No.: 9008-97-3
Synonyms: PHA-M
Category:  

Natural Products Leguminosae Glycine max (L.) merr Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB COX Interleukin Related Reactive Oxygen Species (ROS)

Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, is a T-cell activator. Phytohemagglutinin stimulates human mononuclear leukocytes, inducing the expression of ChAT mRNA and potentiating ACh synthesis. Phytohemagglutinin induces dose- and time-dependent toxicity in THP-1 monocytes/macrophages, alters cellular morphology, causes organelle dysfunction, and increases the expression of NF-κB, COX2, IL-1β .
5
Concanavalin A
Concanavalin A
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5 Cited Publications
Cat. No.: HY-P2149
CAS No.: 11028-71-0
Concanavalin A can be coupled to agarose to form Concanavalin A (agarose) (HY-P2149A). Concanavalin A (ConA) is a selective, competitive binding agent that targets specific carbohydrate structures containing glucose and mannose; it acts as a mitogen and exhibits varying degrees of cytotoxicity, hepatotoxicity, and teratogenicity. Concanavalin A is also utilized for in vivo blood glucose monitoring in the context of diabetes .
2
Curdlan
Curdlan
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2 Cited Publications
Cat. No.: HY-131166
CAS No.: 54724-00-4
Purity:  98.5%
Target:  

Bacterial C-type Lectin-like Receptors (CTLRs) Toll-like Receptor (TLR) NO Synthase Reactive Oxygen Species (ROS)

Research Areas:  

Infection Inflammation/Immunology Cancer

Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages . Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases .
2
5(6)-FITC
5(6)-FITC
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2 Cited Publications
Cat. No.: HY-15941
CAS No.: 27072-45-3
Synonyms: Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
2
Golocdacimab
Golocdacimab
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2 Cited Publications
Cat. No.: HY-P99646
CAS No.: 2418540-63-1
Synonyms: MEDI6570

Target:  

LOX-1

Research Areas:  

Metabolic Disease Inflammation/Immunology

Gocdacimab (MEDI6570) is a fully human IgG1 monoclonal antibody inhibitor targeting the lectin-like oxidized low-density lipoprotein receptor LOX-1. By binding to LOX-1 and blocking its function, gocdacimab effectively reduces the level of free soluble LOX-1, thereby inhibiting key pathological processes such as lipid accumulation, foam cell formation, and vascular wall inflammation. Gocdacimab can interfere with atherosclerosis-related mechanisms, and it is used for research on atherosclerosis, and type 2 diabetes mellitus .
1
Narsoplimab
Narsoplimab
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1 Cited Publications
Cat. No.: HY-P99376
CAS No.: 2108782-45-0
Synonyms: OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)

Target:  

SARS-CoV

Research Areas:  

Infection

Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2 .
1
Methyl α-D-mannopyranoside
Methyl α-D-mannopyranoside
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1 Cited Publications
Cat. No.: HY-W039897
CAS No.: 617-04-9
Synonyms: α-Methyl-D-mannoside
Target:  

Environmental Pollutants Bacterial

Research Areas:  

Infection

Methyl α-D-mannopyranoside (α-Methyl-D-mannoside) is a methyl glycoside derivative and conformational stabilizer of α-D-mannopyranose. The glycosidic bond conformation of Methyl α-D-mannopyranoside is significantly affected by the environment. In aqueous solution, Methyl α-D-mannopyranoside stabilizes into a trans conformation via intermolecular hydrogen bonds; in the gas phase, however, steric interactions drive Methyl α-D-mannopyranoside to prefer a clockwise gauche conformation. Methyl α-D-mannopyranoside also serves as a major component of secondary cell wall polymers in some bacteria and an active precursor site for virus-targeted glycoproteins. Methyl α-D-mannopyranoside acts as an acceptor substrate for alternansucrase, mediating the transfer of D-glucopyranosyl groups to generate a variety of glycosylated oligosaccharide products, with methyl α-D-glucopyranosyl-(1→6)-α-D-mannopyranoside as the main component. Methyl α-D-mannopyranoside is applicable to studies on bacterial pathogenic mechanisms associated with mannose-specific fimbrial lectins .
1
Wheat Germ Agglutinin
Wheat Germ Agglutinin
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1 Cited Publications
Cat. No.: HY-NP091
Synonyms: WGA
Wheat Germ Agglutinin (WGA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Wheat Germ Agglutinin (WGA) is a biological material or organic compound that can be used in life science research .
1
Wheat germ agglutinin-AF555
Wheat germ agglutinin-AF555
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1 Cited Publications
Cat. No.: HY-NP163C
Synonyms: WGA-AF555
Wheat germ agglutinin-AF555 (WGA-AF555) is a membrane-staining lectin conjugate that combines wheat germ agglutinin with the Alexa Fluor 555 fluorescent dye. Wheat germ agglutinin-AF555 is used for precise staining and contour delineation of cell membranes. Wheat germ agglutinin-AF555 also effectively distinguishes between surface vimentin and intracellular vimentin in cells .
1
Peanut Agglutinin (Biotinylated)
Peanut Agglutinin (Biotinylated)
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1 Cited Publications
Cat. No.: HY-NP0182
Synonyms: PNA (Biotinylated)
Peanut Agglutinin (PNA) Biotinylated is a biotinylated lectin that specifically recognizes and binds to the Galβ1-3GalNAc sequence, thereby targeting SPESP1 and TF blood group antigens. As an acrosome-specific marker, Peanut Agglutinin Biotinylated stains mouse spermatocytes and sperm acrosomes with high specificity, and this binding depends not only on SPESP1 but also recognizes other testicular acrosomal glycoproteins. Peanut Agglutinin Biotinylated accurately identifies TF antigens in Reed-Sternberg cells, histiocytosis X cells, and esophageal squamous cell carcinoma, without cross-reacting with non-specific cells. Peanut Agglutinin Biotinylated maintains staining stability in both B-5 and formalin fixatives, and serves as an important tool for the study of Hodgkin's disease, histiocytosis X, and various malignant tumors .
Crovalimab
Crovalimab
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Cat. No.: HY-P99965
CAS No.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107

Target:  

Complement System

Research Areas:  

Cardiovascular Disease Metabolic Disease

Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
PNU-159682 carboxylic acid
PNU-159682 carboxylic acid
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Cat. No.: HY-126666
CAS No.: 1204819-92-0
Purity:  92.02%
Target:  

ADC Payloads

Research Areas:  

Inflammation/Immunology Cancer

PNU-159682 carboxylic acid (Compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .
Concanavalin A-HRP
Concanavalin A-HRP
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Cat. No.: HY-NP164
Synonyms: Con A-HRP
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
Sambucus Nigra Lectin (Biotinylated)
Sambucus Nigra Lectin (Biotinylated)
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Cat. No.: HY-NP0149
Synonyms: SNA (Biotinylated)
Sambucus Nigra Lectin (SNA) (Biotinylated) is a terminal sialic acid (SA) residue-binding lectin with biotinylation modification. Sambucus Nigra Lectin (Biotinylated) binds specifically to terminal sialic acid residues on captured IgG and its subclasses .
Phaseolus vulgaris leucoagglutinin
Phaseolus vulgaris leucoagglutinin
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Cat. No.: HY-NP077
Synonyms: PHA-L
Phaseolus vulgaris leucoagglutinin (PHA-L) is a lectin, that can be extracted from red kidney beans (Phaseolus vulgaris). Phaseolus vulgaris leucoagglutinin can be used as an anterograde axonal tracer in neuroanatomical research to study the morphology of neurons, axons, and terminal structures in the nervous system .
Sambucus Nigra Lectin
Sambucus Nigra Lectin
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Cat. No.: HY-NP080
Synonyms: SNA
Sambucus Nigra Lectin (SNA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) is a biological material or organic compound that can be used in life science research .
Biocytin hydrazide
Biocytin hydrazide
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Cat. No.: HY-147168
CAS No.: 102743-85-1
Purity:  99.24%
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Biocytin hydrazide is a long-chain biotin-containing hydrazide, serving as a biotin-derived active coupling reagent, selective labeling agent and biotinylating reagent. Biocytin hydrazide targets aldehyde, carboxyl, amino and guanidino groups to biotinylate glycoconjugates, K99 lectin, peptides and proteins through its hydrazide moiety, and achieves nonradioactive detection of sialic acid- and galactose-containing glycoconjugates via the avidin–biotin system .
α-L-Rhamnose monohydrate
α-L-Rhamnose monohydrate
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Cat. No.: HY-N0642
CAS No.: 6155-35-7
Category:  

other families Metabolic Disease Plants Disease Research Fields Saccharides Cancer Monosaccharides

Target:  

Drug Derivative Calcium Channel

α-L-Rhamnose monohydrate is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose monohydrate is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose monohydrate induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose monohydrate induces rapid and transient increases in intracellular free Ca 2+ concentration in normal human dermal fibroblasts .
Assay Types