2418540-63-1
Chemical Structure
Golocdacimab
Synonym(s): MEDI6570
- CAS No.: 2418540-63-1
- Formula:N/A
- Molecular Weight:(146.64 kDa)
SMILES: [Golocdacimab]
Biological Activity: Gocdacimab (MEDI6570) is a fully human IgG1 monoclonal antibody inhibitor targeting the lectin-like oxidized low-density lipoprotein receptor LOX-1. By binding to LOX-1 and blocking its function, gocdacimab effectively reduces the level of free soluble LOX-1, thereby inhibiting key pathological processes such as lipid accumulation, foam cell formation, and vascular wall inflammation. Gocdacimab can interfere with atherosclerosis-related mechanisms, and it is used for research on atherosclerosis, and type 2 diabetes mellitus[1][2].
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Golocdacimab | 99.11% | Gocdacimab (MEDI6570) is a fully human IgG1 monoclonal antibody inhibitor targeting the lectin-like oxidized low-density lipoprotein receptor LOX-1. By binding to LOX-1 and blocking its function, gocdacimab effectively reduces the level of free soluble LOX-1, thereby inhibiting key pathological processes such as lipid accumulation, foam cell formation, and vascular wall inflammation. Gocdacimab can interfere with atherosclerosis-related mechanisms, and it is used for research on atherosclerosis, and type 2 diabetes mellitus. | ||||||||||||||||||||
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References
- [1]. Varma V, et al. Identification of Response Biomarkers and Signaling Pathways Associated With the LOX-1 Blockade by MEDI6570 in Type 2 Diabetes[J]. Circulation, 2022, 146(Suppl_1): A11971-A11971.
- [2]. Finocchiaro S, et al. Anti-inflammatory pharmacotherapy in patients with cardiovascular disease. Eur Heart J Cardiovasc Pharmacother. 2025;11(8):712-728. [Content Brief]
