Narsoplimab
Based on 1 publication(s) in Google Scholar
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 2108782-45-0
- Molecular Weight:143.1 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Narsoplimab
More
Biological Activity
Human IgG4 lambda
Human
MASP2
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT and Masp2-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection
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Result:Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 lambda
ELISA, FACS, Functional assay
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Immobilized MASP2 Protein, Human (His) can bind Narsoplimab. The EC50 for this effect is 12.79 ng/mL.
Chemical Information
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CAS No. 2108782-45-0
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Appearance Liquid
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Molecular Weight 143.1 kDa
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Color Colorless to light yellow
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SMILES
[Narsoplimab]
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Synonyms
OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Blood Adv
CG001, a C3b-targeted complement inhibitor blocks three complement pathways: development and preclinical evaluation. [Abstract]2024 Jun 12:bloodadvances.2024012874. PMID: 38865712
Purity & Documentation
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Data Sheet (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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