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mGlu Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (8) Cytochrome P450 (1) EGFR (3) Endogenous Metabolite (3) ERK (1) mGluR (124) p38 MAPK (3) Reference Standards (15)
By Research Areas:	Cancer (11) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (112)

125

Inhibitors & Agonists

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100407

JNJ16259685 3 Publications Verification	mGluR	Neurological Disease
JNJ16259685 is a selective antagonist of **mGlu1 receptor*, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC₅₀* of 19 nM.

HY-70059

LY341495 Maximum Cited Publications 14 Publications Verification	mGluR	Neurological Disease
LY341495 is a *metabotropic glutamate receptor* (mGluR) antagonist with IC₅₀*s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors*, respectively .

HY-103558

LY379268 1 Publications Verification	mGluR	Neurological Disease
LY379268 is a potent, selective and brain-penetrant *mGlu2/3R* agonist with EC₅₀ values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .

HY-100781A

L-AP4 1 Publications Verification L-APB	mGluR	Neurological Disease
L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-W011417

Cinnabarinic acid 1 Publications Verification	Endogenous Metabolite mGluR Apoptosis	Others
Cinnabarinic acid is a specific orthosteric agonist of *mGlu₄* by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis .

HY-15445

CTEP 2 Publications Verification RO 4956371; mGluR5 inhibitor	mGluR	Neurological Disease
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of **mGlu5 receptor with IC₅₀** of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101335

DCG-IV	mGluR	Neurological Disease
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .

HY-18941

Eglumegad 4 Publications Verification LY354740; Eglumetad	mGluR	Neurological Disease
Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC₅₀s of 5 nM and 24 nM on transfected human *mGlu2* and *mGlu3* receptors, respectively.

HY-124419

RO0711401 2 Publications Verification	mGluR	Neurological Disease
RO0711401 is a selective and orally active positive allosteric modulator of **mGlu1 receptor with an EC₅₀** of 56 nM .

HY-108710

VU0650786 2 Publications Verification	mGluR	Neurological Disease
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of *metabotropic glutamate receptor* subtype 3 (mGlu3 NAM), with an IC₅₀** of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents .

HY-119243

LY2794193 1 Publications Verification	mGluR	Neurological Disease
LY2794193 is a highly potent and selective **mGlu3 receptor agonist (hmGlu3 K_i=0.927 nM，EC₅₀=0.47 nM; hmGlu2 K_i=412 nM，EC₅₀**=47.5 nM) .

HY-107982

VU6005649	mGluR	Neurological Disease
VU6005649 is a blood-brain-barrier penetrant **mGlu_7/8 receptor agonist with EC₅₀s of 0.65 μM and 2.6 μM for mGlu₇ receptor and mGlu₈ receptor**, respectively.

HY-100366

Lu AF21934	mGluR	Neurological Disease
Lu AF21934 is a selective and brain-penetrant *mGlu4* receptor positive allosteric modulator with an EC₅₀ of 500 nM for mGlu4 receptor .

HY-101333

CPPG (RS)-CPPG	mGluR	Neurological Disease
CPPG ((RS)-CPPG) is a potent group II/III **mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC₅₀=2.2 nM) over group II (IC₅₀*=46.2 nM) mGlu* receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors .

HY-101845

FITM 1 Publications Verification	mGluR	Cancer
FITM is a negative allosteric modulator of *mGlu1* receptor with a K_i of 2.5 nM.

HY-W011417R

Cinnabarinic acid (Standard)	Endogenous Metabolite Reference Standards mGluR Apoptosis	Others
Cinnabarinic acid (Standard) is the analytical standard of Cinnabarinic acid. This product is intended for research and analytical applications. Cinnabarinic acid is a specific orthosteric agonist of *mGlu₄* by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis .

HY-102095

SIB-1757	mGluR	Neurological Disease
SIB-1757 is a highly selective and noncompetitive antagonist of **mGlu5 receptor with an IC₅₀** of 0.4 μM .

HY-100588

VU0364770	mGluR	Neurological Disease
VU0364770 is a selective and potent positive allosteric modulator (PAM) of *mGlu4. VU0346770 exhibits EC₅₀s of 290 nM and 1.1 μM at rat mGlu4* and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with K_i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively .

HY-117764

LSP4-2022	mGluR	Neurological Disease
LSP4-2022 is a potent and brain-penetrant *mGlu4*-selective orthosteric agonist, with an EC₅₀ of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not *mGlu4* receptor-knockout mice. LSP4-2022 shows pro-depressant activity .

HY-123820

LY3020371 hydrochloride 1 Publications Verification	mGluR	Neurological Disease
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with K_i of 5.3 and 2.5 nM, potently blocks cAMP formation with IC₅₀ of 16.2 nM . LY3020371 hydrochloride exerts an antidepressant-like signature in vivo .

HY-120589

VU0360172	mGluR	Neurological Disease
VU0360172 is a potent and selective **mGlu5 receptor positive allosteric modulator with an EC₅₀ value of 16 nM and a K_i** of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice . VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-110278

ADX71743	mGluR	Neurological Disease
ADX71743 is a highly selective, noncompetitive and brain-penetrant *metabotropic glutamate receptor* 7 negative allosteric modulator (mGlu7 NAM**). ADX71743 can cross the blood-brain barrier (BBB) and possesses anxiolytic activity. .

HY-18941C

Eglumegad hydrochloride 4 Publications Verification LY354740 hydrochloride; Eglumetad hydrochloride	mGluR	Neurological Disease
Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC₅₀s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects .

HY-110146

XAP044	mGluR	Neurological Disease
XAP044 is a potent and selective antagonist of *mGlu7. The metabotropic glutamate receptor* subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms .

HY-114403

VU6012962	mGluR	Neurological Disease
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu₇ NAM) with an IC₅₀ of 347 nM .

HY-120717

VU6001966	mGluR Cytochrome P450	Neurological Disease
VU6001966 is a brain-penetrant and selective *mGlu2* receptor inhibitor. VU6001966 blocks *mGlu2* receptor activity, counteracts LY379268 (HY-103558)-mediated blood-brain barrier protection and inflammatory cytokine dampening in microglia under inflammatory conditions. VU6001966 enhances antidepressant effects when combined with Scopolamine (HY-N0296). VU6001966 can be used for the research of major depressive disorder .

HY-110254

AZD 9272	mGluR	Neurological Disease
AZD 9272 is a selective, orally active and brain penetrant mGluR5 antagonist with IC₅₀s of 2.6 nM and 7.6 nM for rat and human receptors, respectively. AZD 9272 shows >3900-fold selectivity over other mGlu receptors ^2].

HY-70059A

(Rac)-LY341495	mGluR	Neurological Disease
(Rac)-LY341495 is the isomers of LY341495 (HY-70059) can be used as control compounds in experiments. LY341495 is a *metabotropic glutamate receptor* (mGluR) antagonist with IC₅₀*s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors*, respectively .

HY-18760

LY2812223	mGluR	Neurological Disease
LY2812223 is a highly potent, functionally selective **mGlu₂ receptor** agonist with mGlu₂ binding affinity for mGlu₂ and mGlu₃ (K_i=144 nM and 156 nM, respectively) .

HY-101311

UPF-523 AIDA	mGluR	Inflammation/Immunology Cancer
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors *(mGlu1a)* with an IC₅₀ of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis .

HY-103550

A-841720	mGluR	Neurological Disease
A-841720 is a potent, non-competitive and selective **mGlu1 receptor antagonist with an IC₅₀** of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC₅₀ of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research .

HY-15393

VU 0357121	mGluR	Neurological Disease
VU 0357121 is a positive and highly selective *mGlu5R* allosteric modulator (PAM) with an EC₅₀ of 33 nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes .

HY-105040C

Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	mGluR	Neurological Disease
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research .

HY-100605

VU0483605	mGluR	Others
VU0483605 is a potent and brain-penetrated *mGlu₁* receptor positive allosteric modulator (PAM). VU0483605 shows excellent *mGlu₁* PAM activity at both human and rat, with EC₅₀ values of 390 and 356 nM, respectively .

HY-13239

LY2979165	mGluR	Neurological Disease
LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric *mGlu2* receptor agonist .

HY-18162

JNJ-42153605	mGluR	Neurological Disease
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC₅₀ of 17 nM.

HY-100409

PHCCC	mGluR	Cancer
PHCCC is a Group I mGluR antagonist with an IC₅₀ of 3 μM. PHCCC is a selective positive modulator of **mGlu4 receptor**. Antiparkinsonian effect .

HY-103549

Z-Cyclopentyl-AP4	mGluR	Neurological Disease
Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (orthosteric agonist). Z-Cyclopentyl-AP4 is more selective for *mGlu4* than mGlu8 .

HY-14419

TCN238	mGluR	Neurological Disease
TCN238 is an orally bioavailable *mGlu4* receptor positive allosteric modulator (PAM) with an EC₅₀ of 1 μM .

HY-110141

ABP688	mGluR	Others
ABP688 is a high affinity human mGluR5 antagonist with anK_i of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor .

HY-14866

Raseglurant ADX-10059	mGluR	Neurological Disease
Raseglurant (ADX-10059) is a **mGlu5 receptor** negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538)-induced catalepsy in mice .

HY-103559

HexylHIBO	mGluR	Neurological Disease
HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu_1a and mGlu_5a receptors, respectively. HexylHIBO does not inhibits mGlu2 and mGlu4a. HexylHIBO decreased spontaneous excitatory postsynaptic currents (sEPSCs) in rat .

HY-100781B

L-AP4 monohydrate L-APB monohydrate	mGluR	Neurological Disease
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-116855

TASP0433864	mGluR	Neurological Disease
TASP0433864 is a selective positive allosteric modulator (PAM) of metabotropic glutamate 2 (mGlu2) receptor with EC₅₀ values of 199 nM and 206 nM against human and rat mGlu2 receptors, respectively. TASP0433864 has antipsychotic activity .

HY-14554

Pomaglumetad methionil anhydrous LY2140023	mGluR	Neurological Disease
Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research .

HY-105040

Pomaglumetad methionil LY2140023 hydrate	mGluR	Neurological Disease
Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific **mGlu2/3 receptor** agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia .

HY-110191

VU0469650	mGluR	Neurological Disease Cancer
VU0469650 is a potent, selective and brain-penetrant negative allosteric modulator of *mGlu₁* receptor, with an IC₅₀ of 99 nM .

HY-W565924

STX107	mGluR ERK	Neurological Disease
STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pK_i of 8.32. STX107 inhibits glutamate-induced Ca ²⁺ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization .

HY-124372

JNJ-46356479	mGluR	Neurological Disease
JNJ-46356479 is a selective and orally bioavailable **mGlu2 receptor positive allosteric modulator (PAM), with the EC₅₀** of 78 nM. JNJ-46356479 shows active in vivo .

Host:	Mouse (6) Rabbit (1)
Reactivity:	Human (7) Rat (1) Mouse (1)
Application:	IHC-P (4) ICC/IF (4) WB (3) FC (4) ELISA (6)
Isotype:	IgG (1) IgG1 (4) IgG2a (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84578

	Metabotropic Glutamate Receptor 3 Antibody (YA4275) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84569

	Metabotropic Glutamate Receptor 2 Antibody (YA4266) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P83232

	Metabotropic Glutamate Receptor 3 Antibody (YA2977) GLUR3; GPRC1C; GRM3; mGlu3; mGluR3	WB	Human, Mouse, Rat
	Metabotropic Glutamate Receptor 3 Antibody (YA2977) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310

	Metabotropic glutamate receptor 5 Antibody (YA4007) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

HY-P84569A

	Metabotropic Glutamate Receptor 2 Antibody (YA4266)(PBS only) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P84578A

	Metabotropic Glutamate Receptor 3 Antibody (YA4275)(PBS only) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310A

	Metabotropic glutamate receptor 5 Antibody (YA4007)(PBS only) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

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