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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
mitochondrial isoform
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "mitochondrial isoform" in MCE Product Catalog:
2
2 Cited Publications
(Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus .
Cat. No.: HY-139838
CAS No.: 353292-31-6
Epyrifenacil is a protoporphyrinogen oxidase (PPO) inhibiting herbicide, potently targeting the PPO2 isoform from weeds such as Amaranthus palmeri with an IC50 of 0.637 nM. Epyrifenacil also inhibits liver mitochondrial PPO across species, with IC50 values of 2.2 nM (mouse), 2.6 nM (rat), 12.1 nM (rabbit), 7.6 nM (dog), and 10.2 nM (human). Epyrifenacil induces liver tumor development in mice. Epyrifenacil can be used for weed control, and also used as a tool compound in toxicological research to study the mechanism of PPO inhibition, chemical-induced hepatotoxicity, and the mode of action of non-genotoxic carcinogens in rodents [3].
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TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism .
Cat. No.: HY-159509
CAS No.: 2361124-03-8
Synonyms: Claziprotamide; BBP-671
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Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia .
Cat. No.: HY-137782
CAS No.: 18198-76-0
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Cat. No.: HY-130133
CAS No.: 2378831-21-9
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PI3K mTOR Akt Apoptosis Paraptosis p38 MAPK Mitochondrial Metabolism P-glycoprotein CDK MMP HIF/HIF Prolyl-Hydroxylase VEGFR
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DHW-221 is a potent orally active dual PI3K/mTOR inhibitor, exhibiting low nanomolar potency against all four Class I PI3K isoforms and mTOR (PI3Kα, IC50 = 0.50 nM; PI3Kβ, IC50 = 1.9 nM; PI3Kγ, IC50 = 1.8 nM; PI3Kδ, IC50 = 0.74 nM; mTOR, IC50 = 3.9 nM). DHW-221 exerts antitumor effects by blocking the PI3K/Akt/mTOR pathway and inducing mitochondrial apoptosis and paraptosis (via Endoplasmic Reticulum (ER) stress and MAPK signaling) and arrests cell cycle, thereby inhibiting cell migration, invasion and angiogenesis. DHW-221 inhibits tumor growth in both the A549/Taxol (HY-B0015) and the HCC827 xenograft mouse models. DHW-221 can be used for non-small cell lung cancer (NSCLC), colon and breast cancer research .
Cat. No.: HY-137782B
CAS No.: 324518-22-1
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Palmitoleoyl-CoA lithium is the lithium salt form of Palmitoleoyl-CoA (HY-137782). Palmitoleoyl-CoA lithium can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA lithium induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA lithium regulates metabolism via allosteric control of AMPK β1-isoforms .
Cat. No.: HY-137782A
CAS No.: 1246304-41-5
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Palmitoleoyl-CoA triammonium is the triammonium salt form of Palmitoleoyl-CoA (HY-137782). Palmitoleoyl-CoA triammonium can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA triammonium induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA triammonium regulates metabolism via allosteric control of AMPK β1-isoforms .
Cat. No.: HY-P70267
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FH; Fumarate Hydratase isoform 4; Fumarate Hydratase; Fumarate Hydratase isoform 7; Fumarate Hydratase, mitochondrial; Fumarate Hydratase isoform 5; Fumarase; HLRCC; HsFH; MCUL1; Epididymis Secretory Sperm Binding Protein; FMRD; Fumarate Hydratase isoform
Cat. No.: HY-P73062
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FH; Fumarate Hydratase isoform 4; Fumarate Hydratase; Fumarate Hydratase isoform 7; Fumarate Hydratase, mitochondrial; Fumarate Hydratase isoform 5; Fumarase; HLRCC; HsFH; MCUL1; Epididymis Secretory Sperm Binding Protein; FMRD; Fumarate Hydratase isoform
Cat. No.: HY-P75957
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCK2; MtPCK2; Phosphoenolpyruvate Carboxykinase 2, mitochondrial; Phosphoenolpyruvate Carboxykinase 2 (mitochondrial); PEPCK2; Phosphoenolpyruvate Carboxykinase 2 isoform 3; Phosphoenolpyruvate Carboxykinase [GTP], mitochondrial; Epididymis Secretory Sper
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Cat. No.: HY-P71614
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDK3; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, mitochondrial; Pyruvate Dehydrogenase Kinase 3; Pyruvate Dehydrogenase Kinase isoform 3; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 3, mitochondrial; GS1-358P8.4; Pyruvate Dehyd
Cat. No.: HY-P702220
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP5MF; ATP Synthase F Chain, mitochondrial; Prev. ATP5J2; ATP Synthase, H+ Transporting, mitochondrial F0 Complex, Subunit F, isoform 2; ATP5JL; ATP Synthase, H+ Transporting, mitochondrial F0 Complex, Subunit F2; ATP Synthase F(0) Complex Subunit F, Mit
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Cat. No.: HY-P703578
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PDK3; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, mitochondrial; Pyruvate Dehydrogenase Kinase 3; Pyruvate Dehydrogenase Kinase isoform 3; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 3, mitochondrial; GS1-358P8.4; Pyruvate Dehyd
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Cat. No.: HY-P705854
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDK2; PDH Kinase 2; Pyruvate Dehydrogenase Kinase 2; PDKII; PDHK2; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 2, mitochondrial; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 2, mitochondrial; Pyruvate Dehydrogenase Kinase isoform 2
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Cat. No.: HY-184705
HDAC-IN-105 is a histone deacetylase (HDAC) inhibitor with binding to HDAC2 and HDAC4 isoforms. HDAC-IN-105 suppresses HDAC activity via binding within conserved HDAC catalytic pockets. HDAC-IN-105 induces G2/M phase cell cycle arrest. HDAC-IN-105 triggers mitochondrial dysfunction marked by loss of mitochondrial membrane potential. HDAC-IN-105 exhibits growth inhibition in triple-negative breast cancer cells and low toxicity toward normal cells. HDAC-IN-105 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-P85495
Synonyms: AL024441; COX 4; COX IV 1; COX IV; COX IV-1; Cox4; COX41_HUMAN; Cox4a; COX4B; COX4I1; COX4I2; COX4L2; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome C Oxidase subunit IV; Cytochrome c oxidase subunit IV isoform 1; Cytochrome c oxidase subunit IV isoform 2; lung; Cytochrome c oxydase subunit; dJ857M17.2; MGC105470; MGC72016.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
